PMID- 30971952
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 10
DP  - 2019
TI  - Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared 
      to Type 2 Diabetes.
PG  - 320
LID - 10.3389/fphys.2019.00320 [doi]
LID - 320
AB  - As the heterogeneity of diabetes is becoming increasingly clear, opportunities 
      arise for more accurate assessment of factors influencing disease onset, which 
      may lead to more efficient primary prevention. LADA - latent autoimmune diabetes 
      in adults - is a common, hybrid form of diabetes with features of both type 1 and 
      type 2 diabetes. This review aims to summarize current knowledge on the 
      pathophysiological and etiological overlap and differences between LADA and type 
      2 diabetes, discuss similarities between LADA and type 1 diabetes and point at 
      future research needs. Studies conducted to date show a clear genetic overlap 
      between LADA and type 1 diabetes with a high risk conferred by variants in the 
      human leukocyte antigen (HLA) region. In contrast, data from the limited number 
      of studies on lifestyle factors available indicate that LADA may share several 
      environmental risk factors with type 2 diabetes including overweight, physical 
      inactivity, alcohol consumption (protective) and smoking. These factors are known 
      to influence insulin sensitivity, suggesting that insulin resistance, in addition 
      to insulin deficiency due to autoimmune destruction of the beta cells, may play a 
      key role in the pathogenesis of LADA. Moreover, this implies that onset of LADA, 
      similar to type 2 diabetes, to some extent could be prevented or postponed by 
      lifestyle modification such as weight reduction and increased physical activity. 
      The preventive potential of LADA is an important topic to elucidate in future 
      studies, preferably intervention studies.
FAU - Carlsson, Sofia
AU  - Carlsson S
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190326
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6444059
OTO - NOTNLM
OT  - LADA
OT  - epidemiology
OT  - lifestyle
OT  - prevention
OT  - type 2 diabetes
EDAT- 2019/04/12 06:00
MHDA- 2019/04/12 06:01
PMCR- 2019/03/26
CRDT- 2019/04/12 06:00
PHST- 2019/01/04 00:00 [received]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/04/12 06:00 [entrez]
PHST- 2019/04/12 06:00 [pubmed]
PHST- 2019/04/12 06:01 [medline]
PHST- 2019/03/26 00:00 [pmc-release]
AID - 10.3389/fphys.2019.00320 [doi]
PST - epublish
SO  - Front Physiol. 2019 Mar 26;10:320. doi: 10.3389/fphys.2019.00320. eCollection 
      2019.