PMID- 30972158
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 11
IP  - 3
DP  - 2019
TI  - Human umbilical cord mesenchymal stem cells and exosomes: bioactive ways of 
      tissue injury repair.
PG  - 1230-1240
AB  - Mesenchymal stem cells (MSCs) can be recruited to damaged tissues directly for 
      regeneration. Exosomes, acting as an important ingredient of MSCs-involved 
      intercellular communication through paracrine actions, also play significant 
      roles in tissue damage repair and have a prospect of potential clinical 
      application. It is generally recognized that MSC-derived exosomes (MSC-exosomes) 
      enhance tissue regeneration and repair through reducing inflammatory responses, 
      promoting proliferation, inhibiting apoptosis and facilitating angiogenesis. This 
      review summarizes the positive effects of human umbilical cord mesenchymal stem 
      cells (hucMSCs) and hucMSC-derived exosomes (hucMSC-exosomes) on tissue damage 
      and the specific mechanisms of repair action.
FAU - Yin, Siqi
AU  - Yin S
AD  - Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and 
      Transformation Application, Jiangsu Key Laboratory of Medical Science and 
      Laboratory Medicine, School of Medicine, Jiangsu University 301 Xuefu Road, 
      Zhenjiang 212013, Jiangsu, China.
FAU - Ji, Cheng
AU  - Ji C
AD  - Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and 
      Transformation Application, Jiangsu Key Laboratory of Medical Science and 
      Laboratory Medicine, School of Medicine, Jiangsu University 301 Xuefu Road, 
      Zhenjiang 212013, Jiangsu, China.
FAU - Wu, Peipei
AU  - Wu P
AD  - Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and 
      Transformation Application, Jiangsu Key Laboratory of Medical Science and 
      Laboratory Medicine, School of Medicine, Jiangsu University 301 Xuefu Road, 
      Zhenjiang 212013, Jiangsu, China.
FAU - Jin, Can
AU  - Jin C
AD  - Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and 
      Transformation Application, Jiangsu Key Laboratory of Medical Science and 
      Laboratory Medicine, School of Medicine, Jiangsu University 301 Xuefu Road, 
      Zhenjiang 212013, Jiangsu, China.
FAU - Qian, Hui
AU  - Qian H
AD  - Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and 
      Transformation Application, Jiangsu Key Laboratory of Medical Science and 
      Laboratory Medicine, School of Medicine, Jiangsu University 301 Xuefu Road, 
      Zhenjiang 212013, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190315
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC6456565
OTO - NOTNLM
OT  - HucMSC
OT  - exosomes
OT  - tissue injury repair
COIS- None.
EDAT- 2019/04/12 06:00
MHDA- 2019/04/12 06:01
PMCR- 2019/03/15
CRDT- 2019/04/12 06:00
PHST- 2018/12/30 00:00 [received]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/04/12 06:00 [entrez]
PHST- 2019/04/12 06:00 [pubmed]
PHST- 2019/04/12 06:01 [medline]
PHST- 2019/03/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2019 Mar 15;11(3):1230-1240. eCollection 2019.