PMID- 30972327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 7
DP  - 2019
TI  - A Strategy for Prompt Phase Transfer of Upconverting Nanoparticles Through 
      Surface Oleate-Mediated Supramolecular Assembly of Amino-beta-Cyclodextrin.
PG  - 161
LID - 10.3389/fchem.2019.00161 [doi]
LID - 161
AB  - Lanthanide-doped upconverting nanoparticles (UCNPs) are promising for 
      applications as wide as biosensing, bioimaging, controlled drug release, and 
      cancer therapy. These applications require surface engineering of as-prepared 
      nanocrystals, commonly coated with hydrophobic ligand of oleic acid, to enable an 
      aqueous dispersion. However, literature-reported approaches often require a long 
      time and/or multiple step treatment, along with several fold upconversion 
      luminescence (UCL) intensity decrease. Here, we describe a strategy allowing 
      oleate-capped UCNPs to become water-soluble and open-modified, with almost 
      undiminished UCL, through ultrasonication of minutes. The prompt phase transfer 
      was enabled by oleate-mediated supramolecular self-assembly of amino modified 
      beta-cyclodextrin (amino-beta-CD) onto UCNPs surface. We showed that this method is 
      valid for a wide range of UCNPs with quite different sizes (6-400 nm), various 
      dopant types (Er, Tm, and Ho), and hierarchical structures (core, core-shell). 
      Importantly, the amino group of amino-beta-CD on the surface of treated UCNPs 
      provide possibilities to introduce entities for biotargeting or 
      functionalization, as exemplified here, a carboxylic-containing near infrared dye 
      (Cy 7.5) that sensitizes UCNPs to enhance their UCL by ~4,820 fold when excited 
      at ~808 nm. The described method has implications for all types of oleate-capped 
      inorganic nanocrystals, facilitating their myriad bioapplications.
FAU - Wang, Xindong
AU  - Wang X
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, Key Laboratory of Micro-systems and Micro-structures, School of 
      Chemistry and Chemical Engineering, Harbin Institute of Technology, Ministry of 
      Education, Harbin, China.
FAU - Chen, Guanying
AU  - Chen G
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, Key Laboratory of Micro-systems and Micro-structures, School of 
      Chemistry and Chemical Engineering, Harbin Institute of Technology, Ministry of 
      Education, Harbin, China.
LA  - eng
PT  - Journal Article
DEP - 20190327
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC6445860
OTO - NOTNLM
OT  - amino-beta-cyclodextrin
OT  - lanthanides
OT  - phase transfer
OT  - supramolecular self-assembly
OT  - upconverting
EDAT- 2019/04/12 06:00
MHDA- 2019/04/12 06:01
PMCR- 2019/01/01
CRDT- 2019/04/12 06:00
PHST- 2018/11/25 00:00 [received]
PHST- 2019/03/04 00:00 [accepted]
PHST- 2019/04/12 06:00 [entrez]
PHST- 2019/04/12 06:00 [pubmed]
PHST- 2019/04/12 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fchem.2019.00161 [doi]
PST - epublish
SO  - Front Chem. 2019 Mar 27;7:161. doi: 10.3389/fchem.2019.00161. eCollection 2019.