PMID- 30974016
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20220210
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Jan
TI  - Magnetic Resonance Imaging Exploration of the Human Brain During 10 kHz Spinal 
      Cord Stimulation for Failed Back Surgery Syndrome: A Resting State Functional 
      Magnetic Resonance Imaging Study.
PG  - 46-55
LID - 10.1111/ner.12954 [doi]
AB  - INTRODUCTION: Apart from the clinical efficacy of high frequency spinal cord 
      stimulation at 10 kHz, the underlying mechanism of action remains unclear. In 
      parallel with spinal or segmental theories, supraspinal hypotheses have been 
      recently proposed. In order to unveil hidden altered brain connectome patterns, a 
      resting state functional magnetic resonance imaging (rsfMRI) protocol was 
      performed in subjects routinely treated for back and/or leg pain with 
      high-frequency spinal cord stimulation (HF-SCS) HF-SCS at 10 kHz. METHODS: RsfMRI 
      imaging was obtained from ten patients with failed back surgery syndrome who were 
      eligible for HF-SCS at 10 kHz. Specifically-chosen regions of interest with 
      different connectivity networks have been investigated over time. Baseline 
      measurements were compared with measurements after 1 month and 3 months of HF-SCS 
      at 10 kHz. Additionally, clinical parameters on pain intensity, central 
      sensitization, pain catastrophizing, and sleep quality were correlated with the 
      functional connectivity strengths. RESULTS: The study results demonstrate an 
      increased connectivity over time between the anterior insula (affective salience 
      network) and regions of the frontoparietal network and the central executive 
      network. After 3 months of HF-SCS, the increased strength in functional 
      connectivity between the left dorsolateral prefrontal cortex and the right 
      anterior insula was significantly correlated with the minimum clinically 
      important difference (MCID) value of the Pittsburgh sleep quality index. 
      CONCLUSION: These findings support the hypothesis that HF-SCS at 10 kHz might 
      influence the salience network and therefore also the emotional awareness of 
      pain.
CI  - (c) 2019 International Neuromodulation Society.
FAU - De Groote, Sander
AU  - De Groote S
AD  - Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.
FAU - Goudman, Lisa
AU  - Goudman L
AD  - Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.
AD  - Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical 
      Education & Physiotherapy, Vrije Universiteit Brussel, Brussel, Belgium.
FAU - Peeters, Ronald
AU  - Peeters R
AD  - Department of Radiology, Universitair Ziekenhuis Leuven, UZ, Leuven, Belgium.
FAU - Linderoth, Bengt
AU  - Linderoth B
AD  - Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
FAU - Vanschuerbeek, Peter
AU  - Vanschuerbeek P
AD  - Department of Radiology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
FAU - Sunaert, Stefan
AU  - Sunaert S
AD  - Department of Radiology, Universitair Ziekenhuis Leuven, UZ, Leuven, Belgium.
FAU - De Jaeger, Mats
AU  - De Jaeger M
AD  - Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.
FAU - De Smedt, Ann
AU  - De Smedt A
AD  - Department of Neurology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
FAU - Moens, Maarten
AU  - Moens M
AUID- ORCID: 0000-0003-0577-5449
AD  - Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.
AD  - Department of Radiology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
AD  - Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, 
      Belgium.
LA  - eng
GR  - independent research grant/Nevro/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190411
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
SB  - IM
MH  - Aged
MH  - Brain/*diagnostic imaging
MH  - Failed Back Surgery Syndrome/*diagnostic imaging/*therapy
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement/methods
MH  - Prospective Studies
MH  - *Rest
MH  - Spinal Cord Stimulation/*methods
OTO - NOTNLM
OT  - Spinal cord stimulation
OT  - chronic pain
OT  - failed back surgery syndrome
OT  - magnetic resonance imaging
OT  - mechanisms of action
EDAT- 2019/04/12 06:00
MHDA- 2020/11/12 06:00
CRDT- 2019/04/12 06:00
PHST- 2018/12/19 00:00 [received]
PHST- 2019/02/08 00:00 [revised]
PHST- 2019/02/27 00:00 [accepted]
PHST- 2019/04/12 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/04/12 06:00 [entrez]
AID - S1094-7159(21)02067-5 [pii]
AID - 10.1111/ner.12954 [doi]
PST - ppublish
SO  - Neuromodulation. 2020 Jan;23(1):46-55. doi: 10.1111/ner.12954. Epub 2019 Apr 11.