PMID- 30974307
OWN - NLM
STAT- MEDLINE
DCOM- 20191202
LR  - 20191202
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 42
DP  - 2019 Apr
TI  - Cytokine alterations in first-onset postpartum psychosis-clues for underlying 
      immune dysregulation.
PG  - 74-78
LID - S1876-2018(18)31043-8 [pii]
LID - 10.1016/j.ajp.2019.03.012 [doi]
AB  - BACKGROUND: Emerging evidence suggests a possible role for immune system 
      dysregulation in the pathogenesis of postpartum psychosis (PP) but the evidence 
      is limited. The current study sought to determine the serum cytokines/ chemokine 
      changes associated with first-onset PP. METHODS: Women with first onset PP were 
      recruited as cases and the cytokines/ chemokine changes were compared against 
      healthy postpartum (HP) and healthy non-postpartum (HNP) women.There were 20 
      subjects in each of the three groups. Levels of serum cytokines and Monocyte 
      Chemoattractant Protein-1 (MCP-1) were estimated with a cytometric beadarray 
      assay. RESULTS: HP group showed significantly elevated levels of interleukin 
      (IL)-6 as compared to HNP group. Whereas, the first onset PP group showed 
      significantly elevated levels of both IL-6 and IL-8 as compared to HNP group. 
      CONCLUSION: Postpartum period appears to be a state of altered immune functioning 
      considering the elevated level of IL-6 in both HP and PP group. Additionally, 
      IL-8 appears to play a role in the manifestation of PP. Our study highlights the 
      immune alterations associated with first-onset PP.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Sathyanarayanan, Gopinath
AU  - Sathyanarayanan G
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India.
FAU - Thippeswamy, Harish
AU  - Thippeswamy H
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India. Electronic address: docharisht@gmail.com.
FAU - Mani, Reeta
AU  - Mani R
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India.
FAU - Venkataswamy, Manjunatha
AU  - Venkataswamy M
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India.
FAU - Kumar, Mahesh
AU  - Kumar M
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India.
FAU - Philip, Mariamma
AU  - Philip M
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India.
FAU - Chandra, Prabha S
AU  - Chandra PS
AD  - National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 
      560029, Bengaluru, Karnataka, India.
LA  - eng
PT  - Journal Article
DEP - 20190326
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Psychotic Disorders/blood/*immunology
MH  - Puerperal Disorders/blood/*immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Acute Psychosis
OT  - Chemokine
OT  - Cytokine
OT  - Depression
OT  - Immune
OT  - Mania
OT  - Postpartum psychosis
EDAT- 2019/04/12 06:00
MHDA- 2019/12/04 06:00
CRDT- 2019/04/12 06:00
PHST- 2018/12/08 00:00 [received]
PHST- 2019/02/16 00:00 [revised]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/04/12 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2019/04/12 06:00 [entrez]
AID - S1876-2018(18)31043-8 [pii]
AID - 10.1016/j.ajp.2019.03.012 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2019 Apr;42:74-78. doi: 10.1016/j.ajp.2019.03.012. Epub 2019 
      Mar 26.