PMID- 30974698
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 8
IP  - 12
DP  - 2016 Dec 6
TI  - Investigating the Synergistic Effects of Combined Modified Alginates on 
      Macrophage Phenotype.
LID - 10.3390/polym8120422 [doi]
LID - 422
AB  - Understanding macrophage responses to biomaterials is crucial to the success of 
      implanted medical devices, tissue engineering scaffolds, and drug delivery 
      vehicles. Cellular responses to materials may depend synergistically on multiple 
      surface chemistries, due to the polyvalent nature of cell(-)ligand interactions. 
      Previous work in our lab found that different surface functionalities of 
      chemically modified alginate could sway macrophage phenotype toward either the 
      pro-inflammatory or pro-angiogenic phenotype. Using these findings, this research 
      aims to understand the relationship between combined material surface chemistries 
      and macrophage phenotype. Tumor necrosis factor-alpha (TNF-alpha) secretion, nitrite 
      production, and arginase activity were measured and used to determine the ability 
      of the materials to alter macrophage phenotype. Cooperative relationships between 
      pairwise modifications of alginate were determined by calculating synergy values 
      for the aforementioned molecules. Several materials appeared to improve M1 to M2 
      macrophage reprogramming capabilities, giving valuable insight into the 
      complexity of surface chemistries needed for optimal incorporation and survival 
      of implanted biomaterials.
FAU - Bygd, Hannah C
AU  - Bygd HC
AD  - Department of Materials Science & Engineering, Iowa State University, Ames, IA 
      50011, USA. hcbygd@iastate.edu.
FAU - Bratlie, Kaitlin M
AU  - Bratlie KM
AUID- ORCID: 0000-0002-5197-0176
AD  - Department of Materials Science & Engineering, Iowa State University, Ames, IA 
      50011, USA. kbratlie@iastate.edu.
AD  - Department of Chemical & Biological Engineering, Iowa State University, Ames, IA 
      50011, USA. kbratlie@iastate.edu.
AD  - Division of Materials Science & Engineering, Ames National Laboratory, Ames, IA 
      50011, USA. kbratlie@iastate.edu.
LA  - eng
GR  - CBET-122867/National Science Foundation/
GR  - 13-4265/Roy J. Carver Charitable Trust/
PT  - Journal Article
DEP - 20161206
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6432444
OTO - NOTNLM
OT  - TNF-alpha
OT  - alginate
OT  - macrophage phenotype
OT  - synergy
COIS- The authors declare no conflict of interest.
EDAT- 2016/12/06 00:00
MHDA- 2016/12/06 00:01
PMCR- 2016/12/06
CRDT- 2019/04/13 06:00
PHST- 2016/09/30 00:00 [received]
PHST- 2016/11/17 00:00 [revised]
PHST- 2016/12/01 00:00 [accepted]
PHST- 2019/04/13 06:00 [entrez]
PHST- 2016/12/06 00:00 [pubmed]
PHST- 2016/12/06 00:01 [medline]
PHST- 2016/12/06 00:00 [pmc-release]
AID - polym8120422 [pii]
AID - polymers-08-00422 [pii]
AID - 10.3390/polym8120422 [doi]
PST - epublish
SO  - Polymers (Basel). 2016 Dec 6;8(12):422. doi: 10.3390/polym8120422.