PMID- 30975675
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 9
IP  - 4
DP  - 2019 Apr 11
TI  - Differentiating the cognitive development of early-term births in infants and 
      toddlers: a cross-sectional study in China.
PG  - e025275
LID - 10.1136/bmjopen-2018-025275 [doi]
LID - e025275
AB  - OBJECTIVES: This study aimed to explore the cognitive development of low-risk 
      children during early childhood for early-term births at 37 and 38 weeks of 
      gestation compared with full term births at 39-41 weeks of gestation. SETTING AND 
      PARTICIPANTS: We conducted a cross-sectional study in Shanghai, one of the 
      largest cities in China. A total of 1444 children from singleton pregnancies born 
      at term gestation were included in the study. MEASURES: The cognitive outcomes of 
      the subjects were measured using the cognitive subtest of Bayley Scales of Infant 
      and Toddler Development, Third Edition (BSID-III) across three cities in China. 
      We analysed the association between gestational age and cognitive development 
      during infancy and toddler stages using multivariate linear modelling. RESULTS: 
      The cognitive development scores for infants born at 37 gestational weeks were 
      significantly lower than those born at 39-41 gestational weeks (beta=-2.257, 95% CI 
      -4.280 to -0.235; p<0.05) after adjusting for children's and maternal 
      characteristics, as well as socio-economic factors. However, there were no 
      significant differences in cognitive ability between infants born at 38 
      gestational weeks compared with their full-term counterparts (p>0.05). Moreover, 
      these effects were not found in toddlers (between 17 and 48 months of age) after 
      adjusting for the possible confounders (p>0.05). CONCLUSIONS: Infants born at 37 
      weeks of gestation exhibited weaker cognitive ability compared with those born at 
      39-41 weeks of gestation. Our findings provide evidences for the close monitoring 
      of potential developmental problems in early-term children, especially those born 
      at 37 gestational weeks.
CI  - (c) Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Hua, Jing
AU  - Hua J
AD  - The Women and Children's Health Care Department, Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Sun, Jie
AU  - Sun J
AD  - The Women and Children's Health Care Department, Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Cao, Zhijuan
AU  - Cao Z
AD  - The Women and Children's Health Care Department, Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Dai, Xiaotian
AU  - Dai X
AD  - The Women and Children's Health Care Department, Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Lin, Senran
AU  - Lin S
AD  - The Women and Children's Health Care Department, Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Guo, Jialin
AU  - Guo J
AD  - The Women and Children's Health Care Department, Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, Shanghai, China.
FAU - Gu, Guixiong
AU  - Gu G
AD  - Health Statistical Division, Pediatrics Research Institution of Soochow 
      University, Suzhou, China.
FAU - Du, Wenchong
AU  - Du W
AD  - Psychology Division, Nottingham Trent University, Nottingham, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190411
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Child Development/*physiology
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Cognition/*physiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - *Infant, Premature
MH  - Male
MH  - Neurodevelopmental Disorders/*epidemiology
PMC - PMC6500364
OTO - NOTNLM
OT  - China
OT  - cognitive development
OT  - early term
OT  - infants and toddlers
COIS- Competing interests: None declared.
EDAT- 2019/04/13 06:00
MHDA- 2020/04/21 06:00
PMCR- 2019/04/11
CRDT- 2019/04/13 06:00
PHST- 2019/04/13 06:00 [entrez]
PHST- 2019/04/13 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/04/11 00:00 [pmc-release]
AID - bmjopen-2018-025275 [pii]
AID - 10.1136/bmjopen-2018-025275 [doi]
PST - epublish
SO  - BMJ Open. 2019 Apr 11;9(4):e025275. doi: 10.1136/bmjopen-2018-025275.