PMID- 30976808
OWN - NLM
STAT- MEDLINE
DCOM- 20200615
LR  - 20200615
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 111
IP  - 9
DP  - 2019 Sep 1
TI  - Identification of Candidates for Longer Lung Cancer Screening Intervals Following 
      a Negative Low-Dose Computed Tomography Result.
PG  - 996-999
LID - 10.1093/jnci/djz041 [doi]
AB  - Lengthening the annual low-dose computed tomography (CT) screening interval for 
      individuals at lowest risk of lung cancer could reduce harms and improve 
      efficiency. We analyzed 23 328 participants in the National Lung Screening Trial 
      who had a negative CT screen (no >/=4-mm nodules) to develop an individualized 
      model for lung cancer risk after a negative CT. The Lung Cancer Risk Assessment 
      Tool + CT (LCRAT+CT) updates "prescreening risk" (calculated using traditional 
      risk factors) with selected CT features. At the next annual screen following a 
      negative CT, risk of cancer detection was reduced among the 70% of participants 
      with neither CT-detected emphysema nor consolidation (median risk = 0.2%, 
      interquartile range [IQR] = 0.1%-0.3%). However, risk increased for the 30% with 
      CT emphysema (median risk = 0.5%, IQR = 0.3%-0.8%) and the 0.6% with 
      consolidation (median = 1.6%, IQR = 1.0%-2.5%). As one example, a threshold of 
      next-screen risk lower than 0.3% would lengthen the interval for 57.8% of 
      screen-negatives, thus averting 49.8% of next-screen false-positives among 
      screen-negatives but delaying diagnosis for 23.9% of cancers. Our results support 
      that many, but not all, screen-negatives might reasonably lengthen their CT 
      screening interval.
CI  - (c) World Health Organization, 2019. All rights reserved. The World Health 
      Organization has granted the Publisher permission for the reproduction of this 
      article.
FAU - Robbins, Hilary A
AU  - Robbins HA
FAU - Berg, Christine D
AU  - Berg CD
FAU - Cheung, Li C
AU  - Cheung LC
FAU - Chaturvedi, Anil K
AU  - Chaturvedi AK
FAU - Katki, Hormuzd A
AU  - Katki HA
LA  - eng
GR  - U19 CA203654/CA/NCI NIH HHS/United States
GR  - T32 CA009314/CA/NCI NIH HHS/United States
GR  - F31 CA210660/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
SB  - IM
CIN - J Thorac Dis. 2019 Sep;11(Suppl 15):S1916-S1918. PMID: 31632785
CIN - J Thorac Dis. 2019 Sep;11(9):3681-3688. PMID: 31656638
MH  - Age Factors
MH  - Clinical Decision-Making
MH  - *Early Detection of Cancer/methods
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnosis/*epidemiology
MH  - Male
MH  - Mass Screening
MH  - Population Surveillance
MH  - Radiation Dosage
MH  - Time Factors
MH  - *Tomography, X-Ray Computed/methods
PMC - PMC6748798
EDAT- 2019/04/13 06:00
MHDA- 2020/06/17 06:00
PMCR- 2020/04/12
CRDT- 2019/04/13 06:00
PHST- 2018/10/03 00:00 [received]
PHST- 2019/01/23 00:00 [revised]
PHST- 2019/02/22 00:00 [accepted]
PHST- 2019/04/13 06:00 [pubmed]
PHST- 2020/06/17 06:00 [medline]
PHST- 2019/04/13 06:00 [entrez]
PHST- 2020/04/12 00:00 [pmc-release]
AID - 5445482 [pii]
AID - djz041 [pii]
AID - 10.1093/jnci/djz041 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2019 Sep 1;111(9):996-999. doi: 10.1093/jnci/djz041.