PMID- 30977031
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 14
IP  - 5
DP  - 2020 Oct
TI  - Irregular structural networks of gray matter in patients with type 2 diabetes 
      mellitus.
PG  - 1477-1486
LID - 10.1007/s11682-019-00070-2 [doi]
AB  - Type 2 diabetes mellitus (T2DM) induces dementia and cognitive decrements 
      indicating the impairment of the central nervous system. While there is evidence 
      showing abnormalities in white-matter structural networks in T2DM, the 
      topological features of gray matter are still unknown. The study enrolled 30 
      right-handed T2DM patients and 20 healthy control subjects with matched age, 
      gender, handedness, and education. Graph theoretical analysis of magnetic 
      resonance imaging on gray matter volume was conducted to explore large-scale 
      structural networks of brain. Although retaining small-worldness characteristics, 
      the structural networks of grey matter in the T2DM group exhibited an increased 
      clustering coefficient, prolonged characteristic path, decreased global 
      efficiency, and more vulnerability to random failures or targeted attacks 
      compared with controls. Additionally, the degree of structural networks in both 
      T2DM and control groups was distributed exponentially in truncated power law. Our 
      findings suggest that T2DM disturbed the overall topological features of gray 
      matter networks, which provides a novel insight into the neurobiological 
      mechanisms accounting for the cognitive impairment of T2DM patients.
FAU - Cao, Chuanlong
AU  - Cao C
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
FAU - Liu, Wanqing
AU  - Liu W
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China. 
      zhangqingsmile@163.com.
FAU - Wu, Jian-Lin
AU  - Wu JL
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China. 
      cjr.wujianlin@vip.163.com.
FAU - Sun, Yumei
AU  - Sun Y
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
FAU - Li, Danyang
AU  - Li D
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
FAU - Fan, Hongyu
AU  - Fan H
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 
      6, Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
FAU - Wang, Feifei
AU  - Wang F
AD  - Department of MRI, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Diabetes Mellitus, Type 2/diagnostic imaging
MH  - Gray Matter/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *White Matter/diagnostic imaging
OTO - NOTNLM
OT  - Graph theory
OT  - Gray matter
OT  - Network efficiency
OT  - Network robustness
OT  - Structural networks
OT  - Type 2 diabetes
EDAT- 2019/04/13 06:00
MHDA- 2021/04/28 06:00
CRDT- 2019/04/13 06:00
PHST- 2019/04/13 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2019/04/13 06:00 [entrez]
AID - 10.1007/s11682-019-00070-2 [pii]
AID - 10.1007/s11682-019-00070-2 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2020 Oct;14(5):1477-1486. doi: 10.1007/s11682-019-00070-2.