PMID- 30978454
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20200205
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 704
DP  - 2019 Jun 21
TI  - Association between the novel seizure quality index for the outcome prediction in 
      electroconvulsive therapy and brain-derived neurotrophic factor serum levels.
PG  - 164-168
LID - S0304-3940(19)30257-5 [pii]
LID - 10.1016/j.neulet.2019.04.023 [doi]
AB  - The novel Seizure Quality Index (SQI) could predict the risk of non-response and 
      non-remission as early as after the second electroconvulsive therapy (ECT) 
      session based the extent of several ictal parameters of the seizure in patients 
      with depression. The association between those indices with the peripheral serum 
      levels of brain-derived neurotrophic factor (BDNF) was evaluated in this study. 
      It was proposed that seizure quality reflected by the SQI will be positively 
      correlated with the levels of serum BDNF after ECT in patients with depression. 
      We included 36 patients with a full data set, a completed course of ECT and BDNF 
      levels before and after that ECT course. Baseline serum BDNF levels (2838.9 pg/ml 
      +/-1659.9) were lower compared to the mean BDNF levels after ECT (3206.3 pg/ml 
      +/-1532.3), but the statistical test did not reach significance (z = 1.96, 
      p = 0.051, r = 0.23). In a sub-group analysis, the BDNF levels after ECT were 
      positively correlated with the SQI sum score for response (r(s) = 0.62, 
      p = 0.018) and for remission (r(s) = 0.57, p = 0.033) in patients younger than 65 
      years, the group, for whom the SQI has been built and validated. This suggests 
      that one link between seizure quality and antidepressant response to ECT could be 
      BDNF.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Kranaster, Laura
AU  - Kranaster L
AD  - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic 
      address: laura.kranaster@zi-mannheim.de.
FAU - Hellweg, Rainer
AU  - Hellweg R
AD  - Department of Psychiatry, Charite Campus Mitte, Berlin, Germany.
FAU - Sartorius, Alexander
AU  - Sartorius A
AD  - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190409
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Bipolar Disorder/physiopathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder/physiopathology/*therapy
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Electroconvulsive therapy
OT  - Outcome
EDAT- 2019/04/13 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/04/13 06:00
PHST- 2019/01/26 00:00 [received]
PHST- 2019/03/29 00:00 [revised]
PHST- 2019/04/08 00:00 [accepted]
PHST- 2019/04/13 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/04/13 06:00 [entrez]
AID - S0304-3940(19)30257-5 [pii]
AID - 10.1016/j.neulet.2019.04.023 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Jun 21;704:164-168. doi: 10.1016/j.neulet.2019.04.023. Epub 
      2019 Apr 9.