PMID- 30979047 OWN - NLM STAT- MEDLINE DCOM- 20190816 LR - 20200225 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 11 IP - 4 DP - 2019 Apr 11 TI - Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice. LID - 10.3390/nu11040821 [doi] LID - 821 AB - Unhealthy diet promotes progression of metabolic disorders and brain dysfunction with aging. Green tea extracts (GTEs) have various beneficial effects and alleviate metabolic disorders. GTEs have neuroprotective effects in rodent models, but their effects against brain dysfunction in models of aging fed unhealthy diets are still unclear. Here, we showed that GTEs attenuate high-fat (HF) diet-induced brain dysfunction in senescence-accelerated mouse prone-8 (SAMP8), a murine model of senescence. SAMP8 mice were fed a control diet, HF diet, or HF diet with 0.5% GTEs (HFGT) for four months. The HF diet reduced memory retention and induced amyloid beta(1)(-)(42) accumulation, whereas GTEs attenuated these changes. In HF diet-fed mice, lipid oxidative stress, assessed by malondialdehyde levels, was increased. The levels of proteins that promote synaptic plasticity, such as brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95), were reduced. These alterations related to brain dysfunction were not observed in HFGT diet-fed mice. Overall, our data suggest that GTEs intake might attenuate brain dysfunction in HF diet-fed SAMP8 mice by protecting synaptic plasticity as well as via anti-oxidative effects. In conclusion, GTEs might ameliorate unhealthy diet-induced brain dysfunction that develops with aging. FAU - Onishi, Shintaro AU - Onishi S AD - Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. oonishi.shintarou@kao.com. FAU - Meguro, Shinichi AU - Meguro S AD - Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. meguro.shinichi@kao.com. FAU - Pervin, Monira AU - Pervin M AD - Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. gp1747@u-shizuoka-ken.ac.jp. FAU - Kitazawa, Hidefumi AU - Kitazawa H AD - Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. kitazawa.hidefumi@kao.com. FAU - Yoto, Ai AU - Yoto A AD - Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. ai_yoto@hotmail.com. FAU - Ishino, Mayu AU - Ishino M AD - Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16213@u-shizuoka-ken.ac.jp. FAU - Shimba, Yuki AU - Shimba Y AD - Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16214@u-shizuoka-ken.ac.jp. FAU - Mochizuki, Yusuke AU - Mochizuki Y AD - Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16215@u-shizuoka-ken.ac.jp. FAU - Miura, Shinji AU - Miura S AD - Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. miura@u-shizuoka-ken.ac.jp. FAU - Tokimitsu, Ichiro AU - Tokimitsu I AD - Department of Health and Food Science, University of Human Arts and Science, Magome, Iwatsuki-ku, Saitama 339-0077, Japan. ichiro_tokimitsu@human.ac.jp. FAU - Unno, Keiko AU - Unno K AD - Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp. AD - Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp. LA - eng GR - 14-332/Kao Corporation/ PT - Journal Article DEP - 20190411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amyloid beta-Peptides) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Disks Large Homolog 4 Protein) RN - 0 (Neuroprotective Agents) RN - 0 (Plant Extracts) RN - 0 (Synaptophysin) RN - 0 (Tea) MH - Aging MH - Amyloid beta-Peptides/analysis MH - Animals MH - Brain/pathology MH - Brain Chemistry MH - Brain Diseases/*drug therapy/etiology/physiopathology MH - Brain-Derived Neurotrophic Factor/analysis MH - Cognitive Dysfunction/drug therapy/etiology MH - Diet, High-Fat/*adverse effects MH - Disks Large Homolog 4 Protein/analysis MH - Male MH - Memory MH - Mice MH - Neuronal Plasticity MH - *Neuroprotective Agents MH - Organ Size MH - Oxidative Stress/drug effects MH - Phytotherapy MH - Plant Extracts/*administration & dosage MH - Synaptophysin/analysis MH - *Tea PMC - PMC6521105 OTO - NOTNLM OT - aging OT - green tea extracts OT - oxidative stress OT - senescence-accelerated mouse prone-8 OT - synaptic plasticity COIS- The authors had no conflict of interest. EDAT- 2019/04/14 06:00 MHDA- 2019/08/17 06:00 PMCR- 2019/04/01 CRDT- 2019/04/14 06:00 PHST- 2019/03/04 00:00 [received] PHST- 2019/03/26 00:00 [revised] PHST- 2019/04/09 00:00 [accepted] PHST- 2019/04/14 06:00 [entrez] PHST- 2019/04/14 06:00 [pubmed] PHST- 2019/08/17 06:00 [medline] PHST- 2019/04/01 00:00 [pmc-release] AID - nu11040821 [pii] AID - nutrients-11-00821 [pii] AID - 10.3390/nu11040821 [doi] PST - epublish SO - Nutrients. 2019 Apr 11;11(4):821. doi: 10.3390/nu11040821.