PMID- 30979602
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20200316
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 287
DP  - 2019 Jul 15
TI  - The effect of ticagrelor based dual antiplatelet therapy on development of late 
      left ventricular thrombus after acute anterior ST elevation myocardial 
      infarction.
PG  - 19-26
LID - S0167-5273(18)35971-0 [pii]
LID - 10.1016/j.ijcard.2019.04.010 [doi]
AB  - AIM: The aim of this study is to investigate the impact of ticagrelor as compared 
      to clopidogrel based dual antiplatelet therapy (DAPT) during post-discharge 
      management on the incidence of left ventricular (LV) thrombus in patients with 
      first acute anterior ST elevation myocardial infarction (STEMI). METHOD: 641 
      patients who met the inclusion criteria were divided into two groups based on the 
      receipt of either ticagrelor or clopidogrel based DAPT. RESULT: Left ventricular 
      thrombus was detected in 73 (11.4%) patients at the first month echocardiographic 
      examination. Ticagrelor based DAPT was associated with significantly less 
      incidence of LV thrombus when compared to clopidogrel [20 (7.4%) vs 53 (14.0%) 
      OR: 0.50 (0.29-0.86)]. Penalized maximum likelihood estimation (PMLE) logistic 
      regression analyses were performed to fourteen candidate variables for 
      identifying the independent predictors of LV thrombus, ticagrelor (compared with 
      clopidogrel) [OR: 0.53 (0.28-0.96), p = 0.039], body mass index (BMI) [OR: 0.58 
      (0.44-0.77), p < 0.001], KILLIP class (I vs II-IV) [OR: 0.35 (0.14-0.83), 
      p = 0.017], age [OR: 1.22 (1.08-1.40), p < 0.001], poor postprocedural myocardial 
      blush grade (MBG) [OR: 3.35 (1.32-8.15), p = 0.012] and LVEF predischarge [OR: 
      0.79 (0.72-0.86), p < 0.001] were found to be associated with LV thrombus. 
      CONCLUSION: Our study demonstrated that the incidence of LV trombus was 
      significantly lower with ticagrelor than clopidogrel-based DAPT during 
      postdischarge treatment for anterior STEMI patients.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Altintas, Bernas
AU  - Altintas B
AD  - Department of Cardiology, Gazi Yasargil Training and Research Hospital, 
      Diyarbakir, Turkey. Electronic address: bernasaltintas@gmail.com.
FAU - Altindag, Rojhat
AU  - Altindag R
AD  - Department of Cardiology, Diyabakir Gazi Yasargil Training and Research Hospital, 
      Diyarbakir, Turkey.
FAU - Bilge, Onder
AU  - Bilge O
AD  - Department of Cardiology, Diyabakir Gazi Yasargil Training and Research and 
      Education Hospital, Diyarbakir, Turkey.
FAU - Baysal, Erkan
AU  - Baysal E
AD  - Department of Cardiology, Diyabakir Gazi Yasargil Training and Research and 
      Education Hospital, Diyarbakir, Turkey.
FAU - Ozturk, Onder
AU  - Ozturk O
AD  - Department of Cardiology, Diyabakir Gazi Yasargil Training and Research and 
      Education Hospital, Diyarbakir, Turkey.
FAU - Yaylak, Baris
AU  - Yaylak B
AD  - Department Cardiology, Dr.Siyami Ersek Thoracic and Cardiovascular Surgery 
      Training and Research Hospital, Istanbul, Turkey.
FAU - Ede, Huseyin
AU  - Ede H
AD  - Department of Cardiology, Bozok University School of Medicine, Yozgat, Turkey.
FAU - Karahan, Mehmet Zulkif
AU  - Karahan MZ
AD  - Department of Cardiology, Diyabakir Gazi Yasargil Training and Research and 
      Education Hospital, Diyarbakir, Turkey.
FAU - Burak, Cengiz
AU  - Burak C
AD  - Department of Cardiology, Mardin State Hospital, Mardin, Turkey.
FAU - Tanboga, Ibrahim Halil
AU  - Tanboga IH
AD  - Department of Cardiology, Hisar Intercontinental Hospital, Istanbul, Turkey; 
      Department of Biostatistics, Ataturk University Medical School, Erzurum, Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190403
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Purinergic P2Y Receptor Antagonists)
RN  - A74586SNO7 (Clopidogrel)
RN  - GLH0314RVC (Ticagrelor)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Anterior Wall Myocardial Infarction/*complications/diagnosis/drug therapy
MH  - Aspirin/administration & dosage
MH  - Clopidogrel/*administration & dosage
MH  - Coronary Angiography
MH  - Dose-Response Relationship, Drug
MH  - Dual Anti-Platelet Therapy/*methods
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Diseases/epidemiology/etiology/*prevention & control
MH  - Heart Ventricles
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/administration & dosage
MH  - Purinergic P2Y Receptor Antagonists/administration & dosage
MH  - Retrospective Studies
MH  - ST Elevation Myocardial Infarction/*complications/diagnosis/drug therapy
MH  - Thrombosis/epidemiology/etiology/*prevention & control
MH  - Ticagrelor/*administration & dosage
MH  - Treatment Outcome
MH  - Turkey/epidemiology
OTO - NOTNLM
OT  - Anterior ST elevation myocardial infarction
OT  - Clopidogrel
OT  - Dual antiplatelet therapy
OT  - Left ventricular thrombus
OT  - Ticagrelor
EDAT- 2019/04/14 06:00
MHDA- 2020/03/17 06:00
CRDT- 2019/04/14 06:00
PHST- 2018/10/11 00:00 [received]
PHST- 2019/03/30 00:00 [revised]
PHST- 2019/04/02 00:00 [accepted]
PHST- 2019/04/14 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
PHST- 2019/04/14 06:00 [entrez]
AID - S0167-5273(18)35971-0 [pii]
AID - 10.1016/j.ijcard.2019.04.010 [doi]
PST - ppublish
SO  - Int J Cardiol. 2019 Jul 15;287:19-26. doi: 10.1016/j.ijcard.2019.04.010. Epub 
      2019 Apr 3.