PMID- 30980858
OWN - NLM
STAT- MEDLINE
DCOM- 20200817
LR  - 20200817
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 108
IP  - 8
DP  - 2019 Aug
TI  - Investigation of the Size Distribution for Diffusion-Controlled Drug Release From 
      Drug Delivery Systems of Various Geometries.
PG  - 2690-2697
LID - S0022-3549(19)30224-2 [pii]
LID - 10.1016/j.xphs.2019.03.036 [doi]
AB  - Various drug delivery systems (DDSs) are often used in modern medicine to achieve 
      controlled and targeted drug release. Diffusional release of drugs from DDSs is 
      often the main mechanism, especially at early times. Generally, average 
      dimensions of DDS are used to model the drug release, but our recent work on drug 
      release from fibers demonstrated that taking into account diameter distribution 
      is essential. This work systematically investigated the effect of size 
      distribution on diffusional drug release from DDSs of various geometric forms 
      such as membranes, fibers, and spherical particles. The investigation clearly 
      demonstrated that the size distribution has the largest effect on the drug 
      release profiles from spherical particles compared to other geometric forms. 
      Published experimental data for drug release from polymer microparticles and 
      nanoparticles were fitted, and the diffusion coefficients were determined 
      assuming reported radius distributions. Assuming the average radius when fitting 
      the data leads to up to 5 times underestimation of the diffusion coefficient of 
      drug in the polymer.
CI  - Copyright (c) 2019 American Pharmacists Association(R). Published by Elsevier Inc. 
      All rights reserved.
FAU - Spiridonova, Tatiana I
AU  - Spiridonova TI
AD  - Department of Experimental Physics, Tomsk Polytechnic University, 30 Lenin 
      Avenue, Tomsk 634050, Russian Federation.
FAU - Tverdokhlebov, Sergei I
AU  - Tverdokhlebov SI
AD  - Department of Experimental Physics, Tomsk Polytechnic University, 30 Lenin 
      Avenue, Tomsk 634050, Russian Federation.
FAU - Anissimov, Yuri G
AU  - Anissimov YG
AD  - School of Environment and Sciences, Griffith University, Gold Coast, Queensland 
      4222, Australia; Institute of Molecular Medicine, Sechenov First Moscow State 
      Medical University, Moscow, Russia. Electronic address: 
      y.anissimov@griffith.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190411
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polymers)
SB  - IM
MH  - Delayed-Action Preparations/*chemistry
MH  - Diffusion
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Models, Chemical
MH  - Particle Size
MH  - Pharmaceutical Preparations/*administration & dosage/chemistry
MH  - Polymers/*chemistry
OTO - NOTNLM
OT  - controlled drug release
OT  - diffusion
OT  - drug delivery systems
OT  - mathematical modeling
OT  - microparticles
OT  - nanoparticles
EDAT- 2019/04/14 06:00
MHDA- 2020/08/18 06:00
CRDT- 2019/04/14 06:00
PHST- 2019/01/09 00:00 [received]
PHST- 2019/03/11 00:00 [revised]
PHST- 2019/03/29 00:00 [accepted]
PHST- 2019/04/14 06:00 [pubmed]
PHST- 2020/08/18 06:00 [medline]
PHST- 2019/04/14 06:00 [entrez]
AID - S0022-3549(19)30224-2 [pii]
AID - 10.1016/j.xphs.2019.03.036 [doi]
PST - ppublish
SO  - J Pharm Sci. 2019 Aug;108(8):2690-2697. doi: 10.1016/j.xphs.2019.03.036. Epub 
      2019 Apr 11.