PMID- 30981986
OWN - NLM
STAT- MEDLINE
DCOM- 20201104
LR  - 20201104
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 67
DP  - 2019 May
TI  - Western diet consumption through early life induces microvesicular hepatic 
      steatosis in association with an altered metabolome in low birth weight Guinea 
      pigs.
PG  - 219-233
LID - S0955-2863(18)30780-0 [pii]
LID - 10.1016/j.jnutbio.2019.02.009 [doi]
AB  - Uteroplacental insufficiency-induced low birth weight (LBW) and postnatal high 
      saturated fat/high sucrose-fructose diet (Western Diet, WD) consumption have been 
      independently associated with the development of hepatic steatosis, while their 
      additive effect on fatty acid, acylcarnitine and amino acid profiles in early 
      adulthood have not been widely reported. We employed LBW, generated via uterine 
      artery ablation, and normal birth weight (NBW) male guinea pigs fed either a WD 
      or control diet (CD) from weaning to postnatal day 150 (early adulthood). Hepatic 
      steatosis was absent in CD-fed offspring, while NBW/WD offspring displayed 
      macrovesicular steatosis and LBW/WD offspring exhibited microvesicular steatosis, 
      both occurring in a lean phenotype. Life-long consumption of the WD, irrespective 
      of birth weight, was associated with an increase in hepatic medium- and 
      long-chain saturated fatty acids, monounsaturated fatty acids, acylcarnitines, 
      reduced oxidative phosphorylation complex III activity and polyunsaturated fatty 
      acids, and molecular evidence of disrupted hepatic insulin signaling. In NBW/WD, 
      hepatic C15:1 and C16:1n-6 fatty acids in phospholipids, C16, C18 and C18:1 
      acylcarnitines, concentrations of aspartate, phenylalanine, tyrosine and 
      tryptophan and expression of carnitine palmitoyltransferase 1 alpha (CPT1alpha) and 
      uncoupling protein 2 (UCP2) genes were elevated compared to LBW/WD livers. Our 
      results suggest that LBW and life-long WD combined are influential in promoting 
      hepatic microvesicular steatosis in conjunction with a specific mitochondrial 
      gene expression and metabolomic profile in early adulthood.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Sarr, Ousseynou
AU  - Sarr O
AD  - Department of Obstetrics and Gynaecology, Western University, London, Ontario, 
      Canada; Lawson Health Research Institute, London, Ontario, Canada; Children's 
      Health Research Institute, London, Ontario, Canada.
FAU - Mathers, Katherine E
AU  - Mathers KE
AD  - Department of Physiology and Pharmacology, Western University.
FAU - Zhao, Lin
AU  - Zhao L
AD  - Department of Obstetrics and Gynaecology, Western University, London, Ontario, 
      Canada.
FAU - Dunlop, Kristyn
AU  - Dunlop K
AD  - Department of Physiology and Pharmacology, Western University.
FAU - Chiu, Jacky
AU  - Chiu J
AD  - Department of Physiology and Pharmacology, Western University.
FAU - Guglielmo, Christopher G
AU  - Guglielmo CG
AD  - Department of Biology, Western University.
FAU - Bureau, Yves
AU  - Bureau Y
AD  - Department of Medical Biophysics, Western University.
FAU - Cheung, Anson
AU  - Cheung A
AD  - Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
FAU - Raha, Sandeep
AU  - Raha S
AD  - Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
FAU - Lee, Ting-Yim
AU  - Lee TY
AD  - Lawson Health Research Institute, London, Ontario, Canada; Departments of Medical 
      Imaging, Medical Biophysics, and Oncology, Western University; Robarts Research 
      Institute, London, Ontario, Canada.
FAU - Regnault, Timothy R H
AU  - Regnault TRH
AD  - Department of Obstetrics and Gynaecology, Western University, London, Ontario, 
      Canada; Lawson Health Research Institute, London, Ontario, Canada; Children's 
      Health Research Institute, London, Ontario, Canada; Department of Physiology and 
      Pharmacology, Western University. Electronic address: tim.regnault@uwo.ca.
LA  - eng
GR  - MOP-209113/CIHR/Canada
GR  - MOP-136837/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190310
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Fatty Acids)
RN  - 0 (acylcarnitine)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Birth Weight
MH  - Carnitine/analogs & derivatives/metabolism
MH  - Diet, Western/*adverse effects
MH  - Fatty Acids/metabolism
MH  - Female
MH  - Guinea Pigs
MH  - Lipogenesis
MH  - Liver/pathology/physiology
MH  - Metabolome/*drug effects
MH  - Non-alcoholic Fatty Liver Disease/*etiology
MH  - Placental Insufficiency/etiology
MH  - Pregnancy
MH  - Weight Gain
OTO - NOTNLM
OT  - Acylcarnitine
OT  - Amino Acid
OT  - Fatty Liver
OT  - IUGR
OT  - NAFLD
OT  - Western Diet
EDAT- 2019/04/15 06:00
MHDA- 2020/11/05 06:00
CRDT- 2019/04/15 06:00
PHST- 2018/08/10 00:00 [received]
PHST- 2019/02/20 00:00 [revised]
PHST- 2019/02/28 00:00 [accepted]
PHST- 2019/04/15 06:00 [pubmed]
PHST- 2020/11/05 06:00 [medline]
PHST- 2019/04/15 06:00 [entrez]
AID - S0955-2863(18)30780-0 [pii]
AID - 10.1016/j.jnutbio.2019.02.009 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2019 May;67:219-233. doi: 10.1016/j.jnutbio.2019.02.009. Epub 
      2019 Mar 10.