PMID- 30982023
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20220408
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 24
IP  - 6
DP  - 2018 Nov
TI  - Specific Immunoglobulin G4 and Immunoglobulin E Titers to Common Food Antigens in 
      Sera of Children With Allergic Rhinitis.
PG  - 38-45
AB  - CONTEXT: Allergic rhinitis is a chronic disease that usually affects children. 
      Its etiology has been investigated for years. OBJECTIVE: The aim of the study was 
      to evaluate the diagnostic value of immunoglobulin G4 (IgG4) against common food 
      allergens, to determine the correlation between it and immunoglobulin E (IgE), 
      and to evaluate the role of IgG4 (ie, whether its presence should be considered 
      to be a significant factor that induces hypersensitivity or whether an effector 
      role in allergic rhinitis could be attributed to it). DESIGN: This research was 
      conducted as a randomized controlled trial. SETTING: The research team performed 
      the study in the Department of Otolaryngology and Sleep Center, Cheng Ching 
      General Hospital-Chung Kang Branch (Taichung, Taiwan). PARTICIPANTS: The 
      participants were 46 patients-29 boys and 17 girls-with an average age of 8.02 +/- 
      2.92 y-who had been diagnosed with allergic rhinitis. OUTCOME MEASURES: Blood 
      samples were collected from the participants. The total IgE, food-specific IgE, 
      and food-specific IgG4 in their sera were measured using the proprietary BioIC 
      system, which is based on the principles of the enzyme-linked immunosorbent assay 
      (ELISA). RESULTS: In terms of total IgE, 20 patients (43.5%) had a concentration 
      of <1000 IU/mL. Regarding specific IgG4, 89.1% of patients were highly reactive 
      to egg white IgG4, whereas >50% were highly reactive to egg yolk, milk, peanuts, 
      almonds, wheat, and soybeans. Regression analysis to test the correlation between 
      specific IgE and specific IgG4 revealed that egg whites, milk, peanuts, and 
      almonds had significant correlations (P < .05). Cod, shrimp, and crab showed very 
      significant correlations (P < .001). CONCLUSION: Total IgE varies widely in 
      children with allergic rhinitis but remains one of the references for diagnosis. 
      The main inhalational allergens are dust mites, followed by grass pollen, molds, 
      German cockroach, and animal dander. Food allergy generates highly concentrated 
      IgG4 and may play a role in children with allergic rhinitis.
FAU - Liu, Po-Jen
AU  - Liu PJ
FAU - Liu, Kai-Li
AU  - Liu KL
FAU - Liao, En-Chih
AU  - Liao EC
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Egg Hypersensitivity
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Immunoglobulin G/*blood
MH  - Male
MH  - Rhinitis, Allergic/blood/*diagnosis/immunology
MH  - Taiwan
EDAT- 2019/04/15 06:00
MHDA- 2019/04/23 06:00
CRDT- 2019/04/15 06:00
PHST- 2019/04/15 06:00 [entrez]
PHST- 2019/04/15 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
PST - ppublish
SO  - Altern Ther Health Med. 2018 Nov;24(6):38-45.