PMID- 30984191
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20200804
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Autoimmune Theories of Chronic Spontaneous Urticaria.
PG  - 627
LID - 10.3389/fimmu.2019.00627 [doi]
LID - 627
AB  - Urticaria (hives) is a highly prevalent skin disorder that can occur with or 
      without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition 
      which persists for more than 6 weeks in duration and occurs in the absence of an 
      identifiable provoking factor. CSU results from pathogenic activation of mast 
      cells and basophils, which gives rise to the release of proinflammatory mediators 
      that support the generation of urticaria. Several theories have been put forth 
      regarding the pathogenesis of CSU with much evidence pointing toward a potential 
      autoimmune etiology in up to 50% of patients with this condition. In this review, 
      we highlight the evidence surrounding the autoimmune pathogenesis of chronic 
      urticaria including recent data which suggests that CSU may involve contributions 
      from both immunoglobin G (IgG)-specific and immunoglobulin E (IgE)-specific 
      autoantibodies against a vast array of antigens that can span beyond those found 
      on the surface of mast cells and basophils.
FAU - Bracken, Sonali J
AU  - Bracken SJ
AD  - Department of Internal Medicine, Duke University School of Medicine, Durham, NC, 
      United States.
FAU - Abraham, Soman
AU  - Abraham S
AD  - Department of Pathology, Duke University Medical Center, Durham, NC, United 
      States.
AD  - Department of Immunology, Duke University Medical Center, Durham, NC, United 
      States.
FAU - MacLeod, Amanda S
AU  - MacLeod AS
AD  - Department of Immunology, Duke University Medical Center, Durham, NC, United 
      States.
AD  - Department of Dermatology, Duke University Medical Center, Durham, NC, United 
      States.
LA  - eng
GR  - R01 AI139207/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20190329
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Basophils/*immunology/pathology
MH  - Chronic Urticaria/*immunology/pathology
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Immunoglobulin G/*immunology
MH  - Mast Cells/*immunology/pathology
MH  - *Models, Immunological
PMC - PMC6450064
OTO - NOTNLM
OT  - anti-FcepsilonR1
OT  - anti-IgE
OT  - anti-TPO
OT  - autoallergy
OT  - autoimmune urticaria
OT  - chronic idiopathic urticaria
OT  - chronic spontaneous urticaria
EDAT- 2019/04/16 06:00
MHDA- 2020/08/05 06:00
PMCR- 2019/01/01
CRDT- 2019/04/16 06:00
PHST- 2019/01/23 00:00 [received]
PHST- 2019/03/08 00:00 [accepted]
PHST- 2019/04/16 06:00 [entrez]
PHST- 2019/04/16 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.00627 [doi]
PST - epublish
SO  - Front Immunol. 2019 Mar 29;10:627. doi: 10.3389/fimmu.2019.00627. eCollection 
      2019.