PMID- 30985344
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20200701
IS  - 1473-6586 (Electronic)
IS  - 0963-0643 (Print)
IS  - 0963-0643 (Linking)
VI  - 29
IP  - 4
DP  - 2019 Jul
TI  - Electrical stimulation for neuroregeneration in urology: a new therapeutic 
      paradigm.
PG  - 458-465
LID - 10.1097/MOU.0000000000000632 [doi]
AB  - PURPOSE OF REVIEW: The present review highlights regenerative electrical 
      stimulation (RES) as potential future treatment options for patients with nerve 
      injuries leading to urological dysfunction, such as urinary incontinence, voiding 
      dysfunction or erectile dysfunction. Additionally, it will highlight the 
      mechanism of nerve injury and regeneration as well as similarities and 
      differences between RES and current electrical stimulation treatments in urology, 
      functional electrical stimulation (FES) and neuromodulation. RECENT FINDINGS: It 
      has been demonstrated that RES upregulates brain-derived neurotrophic factor 
      (BDNF) and its receptor to facilitate neuroregeneration, facilitating accurate 
      reinnervation of muscles by motoneurons. Further, RES upregulates growth factors 
      in glial cells. Within the past 2 years, RES of the pudendal nerve upregulated 
      BDNF in Onuf's nucleus, the cell bodies of motoneurons that course through the 
      pudendal nerve and accelerated functional recovery in an animal model of stress 
      urinary incontinence. Additionally, electrical stimulation of the vaginal tissue 
      in an animal model of stress urinary incontinence accelerated functional 
      recovery. SUMMARY: RES has great potential but future research is needed to 
      expand the potential beneficial effects of RES in the field of urology.
FAU - Balog, Brian M
AU  - Balog BM
AD  - Department of Biomedical Engineering, Lerner Research Institute, Cleveland 
      Clinic.
AD  - Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs 
      Medical Center, Cleveland.
AD  - Department of Biology, University of Akron, Akron, Ohio, USA.
FAU - Deng, Kangli
AU  - Deng K
AD  - Department of Urology, Hubei Cancer Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, PR China.
FAU - Labhasetwar, Vinod
AU  - Labhasetwar V
AD  - Department of Biomedical Engineering, Lerner Research Institute, Cleveland 
      Clinic.
FAU - Jones, Kathryn J
AU  - Jones KJ
AD  - Department of Anatomy and Cell Biology, School of Medicine, Indiana University.
AD  - Research and Development, Richard L. Roudebush VA, Indianapolis, Indiana.
FAU - Damaser, Margot S
AU  - Damaser MS
AD  - Department of Biomedical Engineering, Lerner Research Institute, Cleveland 
      Clinic.
AD  - Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs 
      Medical Center, Cleveland.
AD  - Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
LA  - eng
GR  - F9261-L/RD/ORD VA/United States
GR  - I01 RX001262/RX/RRD VA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Curr Opin Urol
JT  - Current opinion in urology
JID - 9200621
SB  - IM
MH  - Animals
MH  - Electric Stimulation Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Male Urogenital Diseases/etiology/*therapy
MH  - Models, Animal
MH  - Nerve Regeneration/*physiology
MH  - Peripheral Nerve Injuries/complications/*therapy
PMC - PMC6946058
MID - NIHMS1056643
COIS- Conflicts of Interest None
EDAT- 2019/04/16 06:00
MHDA- 2020/03/17 06:00
PMCR- 2020/07/01
CRDT- 2019/04/16 06:00
PHST- 2019/04/16 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
PHST- 2019/04/16 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.1097/MOU.0000000000000632 [doi]
PST - ppublish
SO  - Curr Opin Urol. 2019 Jul;29(4):458-465. doi: 10.1097/MOU.0000000000000632.