PMID- 30985867
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20210109
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 104
IP  - 9
DP  - 2019 Sep 1
TI  - Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal 
      Women Using Mathematical Modeling.
PG  - 3628-3636
LID - 10.1210/jc.2018-02797 [doi]
AB  - BACKGROUND: Hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones 
      regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) 
      consistently synchronizes with the LH pulse, implicating the hypothalamic KNDy 
      neurones in generating LH pulsatility and HF. Using a modern immunoassay and 
      mathematical modeling, we investigated if the HF and LH pulse were consistently 
      synchronized in menopausal women. METHODS: Eleven menopausal women (51 to 62 
      years of age and experiencing >/=7 HF in 24 hours) participated in an 8-hour study. 
      Subjects self-reported HF and underwent peripheral blood sampling every 10 
      minutes. LH pulsatility was determined using two mathematical models: blinded 
      deconvolution analysis and Bayesian spectrum analysis. The probability that the 
      LH pulse and HF event intervals matched was estimated using the interval 
      distributions observed in our data. RESULTS: Ninety-six HFs were self-reported, 
      and 82 LH pulses were identified by blinded deconvolution analysis. Using both 
      models, the probability that the two event intervals matched was low in the 
      majority of participants (mean P = 0.24; P = 1 reflects perfect association). 
      INTERPRETATION: Our data challenge the widely accepted dogma that HFs 
      consistently synchronize with an LH pulse and therefore have clinically important 
      therapeutic and mechanistic implications.
CI  - Copyright (c) 2019 Endocrine Society.
FAU - Prague, Julia K
AU  - Prague JK
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
FAU - Voliotis, Margaritis
AU  - Voliotis M
AD  - College of Engineering, Mathematics, and Physical Sciences, University of Exeter, 
      Exeter, United Kingdom.
AD  - EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, 
      Exeter, United Kingdom.
FAU - Clarke, Sophie
AU  - Clarke S
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
FAU - Comninos, Alexander N
AU  - Comninos AN
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
AD  - Department of Endocrinology, Imperial College Healthcare NHS Trust, London, 
      United Kingdom.
FAU - Abbara, Ali
AU  - Abbara A
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
FAU - Jayasena, Channa N
AU  - Jayasena CN
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
FAU - Roberts, Rachel E
AU  - Roberts RE
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
FAU - Yang, Lisa
AU  - Yang L
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
FAU - Veldhuis, Johannes D
AU  - Veldhuis JD
AD  - Mayo Clinic, Rochester, Minnesota.
FAU - Tsaneva-Atanasova, Krasimira
AU  - Tsaneva-Atanasova K
AD  - College of Engineering, Mathematics, and Physical Sciences, University of Exeter, 
      Exeter, United Kingdom.
AD  - EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, 
      Exeter, United Kingdom.
AD  - Living Systems Institute, University of Exeter, Exeter, United Kingdom.
FAU - McArdle, Craig A
AU  - McArdle CA
AD  - Bristol Medical School, University of Bristol, Bristol, United Kingdom.
FAU - Dhillo, Waljit S
AU  - Dhillo WS
AD  - Section of Endocrinology & Investigative Medicine, Imperial College, London, 
      United Kingdom.
LA  - eng
GR  - MR/M024954/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/R000484/1/MRC_/Medical Research Council/United Kingdom
GR  - RP-2014-05-001/DH_/Department of Health/United Kingdom
GR  - CDF-2009-02-05/DH_/Department of Health/United Kingdom
GR  - CS-2018-18-ST2-002/DH_/Department of Health/United Kingdom
GR  - PDF-2017-10-098/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - Hot Flashes/blood/*physiopathology
MH  - Humans
MH  - Luteinizing Hormone/*blood
MH  - Menopause/blood/*physiology
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Prognosis
MH  - *Pulsatile Flow
PMC - PMC6637789
EDAT- 2019/04/16 06:00
MHDA- 2020/05/28 06:00
PMCR- 2019/04/15
CRDT- 2019/04/16 06:00
PHST- 2018/12/27 00:00 [received]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/04/16 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/04/16 06:00 [entrez]
PHST- 2019/04/15 00:00 [pmc-release]
AID - 5450539 [pii]
AID - 201802797 [pii]
AID - 10.1210/jc.2018-02797 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2019 Sep 1;104(9):3628-3636. doi: 10.1210/jc.2018-02797.