PMID- 30986779
OWN - NLM
STAT- MEDLINE
DCOM- 20200101
LR  - 20200101
IS  - 1361-6528 (Electronic)
IS  - 0957-4484 (Linking)
VI  - 30
IP  - 32
DP  - 2019 Aug 9
TI  - Detection of ultra-low protein concentrations with the simplest possible field 
      effect transistor.
PG  - 324001
LID - 10.1088/1361-6528/ab192c [doi]
AB  - Silicon nanowire (Si NW) sensors have attracted great attention due to their 
      ability to provide fast, low-cost, label-free, real-time detection of chemical 
      and biological species. Usually configured as field effect transistors (FETs), 
      they have already demonstrated remarkable sensitivity with high selectivity 
      (through appropriate functionalisation) towards a large number of analytes in 
      both liquid and gas phases. Despite these excellent results, Si NW FET sensors 
      have not yet been successfully employed to detect single molecules of either a 
      chemical or biological target species. Here we show that sensors based on silicon 
      junctionless nanowire transistors (JNTs), the simplest possible transistors, are 
      capable of detecting the protein streptavidin at a concentration as low as 580 zM 
      closely approaching the single molecule level. This ultrahigh detection 
      sensitivity is due to the intrinsic advantages of junctionless devices over 
      conventional FETs. Apart from their superior functionality, JNTs are much easier 
      to fabricate by standard microelectronic processes than transistors containing 
      p-n junctions. The ability of JNT sensors to detect ultra-low concentrations (in 
      the zeptomolar range) of target species, and their potential for low-cost mass 
      production, will permit their deployment in numerous environments, including life 
      sciences, biotechnology, medicine, pharmacology, product safety, environmental 
      monitoring and security.
FAU - Georgiev, Yordan M
AU  - Georgiev YM
AD  - Materials Chemistry & Analysis Group, Department of Chemistry and Tyndall 
      National Institute, University College Cork, Lee Maltings, Dyke Parade, Cork, 
      Ireland. Centre for Research on Adaptive Nanostructures and Nanodevices 
      (CRANN/AMBER), Trinity College Dublin, Dublin 2, Ireland.
FAU - Petkov, Nikolay
AU  - Petkov N
FAU - Yu, Ran
AU  - Yu R
FAU - Nightingale, Adrian M
AU  - Nightingale AM
FAU - Buitrago, Elizabeth
AU  - Buitrago E
FAU - Lotty, Olan
AU  - Lotty O
FAU - deMello, John C
AU  - deMello JC
FAU - Ionescu, Adrian
AU  - Ionescu A
FAU - Holmes, Justin D
AU  - Holmes JD
LA  - eng
PT  - Journal Article
DEP - 20190415
PL  - England
TA  - Nanotechnology
JT  - Nanotechnology
JID - 101241272
RN  - 0 (Proteins)
RN  - 9013-20-1 (Streptavidin)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Biosensing Techniques/instrumentation/*methods
MH  - Limit of Detection
MH  - Nanowires/chemistry
MH  - Proteins/*analysis
MH  - Silicon/chemistry
MH  - Streptavidin/analysis
MH  - *Transistors, Electronic
EDAT- 2019/04/16 06:00
MHDA- 2020/01/02 06:00
CRDT- 2019/04/16 06:00
PHST- 2019/04/16 06:00 [pubmed]
PHST- 2020/01/02 06:00 [medline]
PHST- 2019/04/16 06:00 [entrez]
AID - 10.1088/1361-6528/ab192c [doi]
PST - ppublish
SO  - Nanotechnology. 2019 Aug 9;30(32):324001. doi: 10.1088/1361-6528/ab192c. Epub 
      2019 Apr 15.