PMID- 30986927
OWN - NLM
STAT- MEDLINE
DCOM- 20190730
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 7
DP  - 2019 Apr 2
TI  - Molecular Mechanisms Controlled by mTOR in Male Reproductive System.
LID - 10.3390/ijms20071633 [doi]
LID - 1633
AB  - In recent years, the mammalian target of rapamycin (mTOR) has emerged as a master 
      integrator of upstream inputs, such as amino acids, growth factors and insulin 
      availability, energy status and many others. The integration of these signals 
      promotes a response through several downstream effectors that regulate protein 
      synthesis, glucose metabolism and cytoskeleton organization, among others. All 
      these biological processes are essential for male fertility, thus it is not 
      surprising that novel molecular mechanisms controlled by mTOR in the male 
      reproductive tract have been described. Indeed, since the first clinical evidence 
      showed that men taking rapamycin were infertile, several studies have evidenced 
      distinct roles for mTOR in spermatogenesis. However, there is a lack of consensus 
      whether mTOR inhibition, which remains the experimental approach that originates 
      the majority of available data, has a negative or positive impact on male 
      reproductive health. Herein we discuss the latest findings concerning mTOR 
      activity in testes, particularly its role on spermatogonial stem cell (SSC) 
      maintenance and differentiation, as well as in the physiology of Sertoli cells 
      (SCs), responsible for blood-testis barrier maintenance/restructuring and the 
      nutritional support of spermatogenesis. Taken together, these recent advances 
      highlight a crucial role for mTOR in determining the male reproductive potential.
FAU - Moreira, Bruno P
AU  - Moreira BP
AUID- ORCID: 0000-0002-8584-4979
AD  - Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical 
      Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in 
      Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal. 
      brunommoreira9@gmail.com.
FAU - Oliveira, Pedro F
AU  - Oliveira PF
AUID- ORCID: 0000-0002-4989-5699
AD  - Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical 
      Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in 
      Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal. 
      pfobox@gmail.com.
AD  - i3S-Instituto de Investigacao e Inovacao em Saude, University of Porto, 4200-135 
      Porto, Portugal. pfobox@gmail.com.
AD  - Department of Genetics, Faculty of Medicine, University of Porto, 4200-450 Porto, 
      Portugal. pfobox@gmail.com.
FAU - Alves, Marco G
AU  - Alves MG
AUID- ORCID: 0000-0001-7635-783X
AD  - Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical 
      Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in 
      Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal. 
      alvesmarc@gmail.com.
LA  - eng
GR  - IFCT2015; PTDC/BIM-MET/4712/2014; PTDC/BBB-BQB/1368/2014; 
      PTDC/MEC-AND/28691/2017/Fundacao para a Ciencia e a Tecnologia/
PT  - Journal Article
PT  - Review
DEP - 20190402
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
MH  - Animals
MH  - Genitalia, Male/*metabolism
MH  - Humans
MH  - Male
MH  - Models, Biological
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Testis/metabolism
PMC - PMC6480367
OTO - NOTNLM
OT  - Sertoli cells
OT  - mTOR
OT  - male fertility
OT  - spermatogenesis
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2019/04/17 06:00
MHDA- 2019/07/31 06:00
PMCR- 2019/04/01
CRDT- 2019/04/17 06:00
PHST- 2019/03/12 00:00 [received]
PHST- 2019/03/27 00:00 [revised]
PHST- 2019/03/28 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/07/31 06:00 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - ijms20071633 [pii]
AID - ijms-20-01633 [pii]
AID - 10.3390/ijms20071633 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Apr 2;20(7):1633. doi: 10.3390/ijms20071633.