PMID- 30987714
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20220809
IS  - 2224-6614 (Electronic)
IS  - 1021-9498 (Print)
VI  - 27
IP  - 2
DP  - 2019 Apr
TI  - Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray 
      ionization mass spectrometry.
PG  - 428-438
LID - 10.1016/j.jfda.2018.09.002 [doi]
AB  - Determination of drugs-of-abuse in body fluids of drug abusers is important for 
      the law enforcement as well as the treatment and rehabilitation. In this study, 
      wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and 
      cost-effective technique, was developed for rapid detection and quantitation of 
      common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine 
      (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, 
      following our previous successful demonstration for rapid and sensitive detection 
      of ketamine and nor-ketamine in urine and oral fluid by this technique. It was 
      found that the limit-of-detection for methamphetamine could fully fulfill the 
      cut-off value requirements of the international standards, and those of MDMA and 
      cocaine could fulfill some of the requirements. The linear range, accuracy and 
      precision for quantitation of the drugs were generally satisfactory, except for 
      THC for which the analytical performance still needs to be improved. Analysis of 
      one sample could typically be completed within minutes. These results indicated 
      that WT-ESI-MS could be used for rapid screening of drugs-of-abuse in urine, oral 
      fluid as well as other body fluids.
CI  - Copyright (c) 2018. Published by Elsevier Taiwan LLC.
FAU - Ng, Tsz-Tsun
AU  - Ng TT
AD  - State Key Laboratory of Chemical Biology and Drug Discovery, Food Safety and 
      Technology Research Centre, Department of Applied Biology and Chemical 
      Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special 
      Administrative Region, Kowloon, China.
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), 
      Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research 
      Institute of Hong Kong Polytechnic University, Shenzhen, 518057, China.
FAU - So, Pui-Kin
AU  - So PK
AD  - State Key Laboratory of Chemical Biology and Drug Discovery, Food Safety and 
      Technology Research Centre, Department of Applied Biology and Chemical 
      Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special 
      Administrative Region, Kowloon, China.
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), 
      Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research 
      Institute of Hong Kong Polytechnic University, Shenzhen, 518057, China.
FAU - Hu, Bin
AU  - Hu B
AD  - State Key Laboratory of Chemical Biology and Drug Discovery, Food Safety and 
      Technology Research Centre, Department of Applied Biology and Chemical 
      Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special 
      Administrative Region, Kowloon, China.
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), 
      Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research 
      Institute of Hong Kong Polytechnic University, Shenzhen, 518057, China.
AD  - Institute of Mass Spectrometer and Atmospheric Environment, Jinan University, 
      Guangzhou, 510632, China.
FAU - Yao, Zhong-Ping
AU  - Yao ZP
AD  - State Key Laboratory of Chemical Biology and Drug Discovery, Food Safety and 
      Technology Research Centre, Department of Applied Biology and Chemical 
      Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special 
      Administrative Region, Kowloon, China.
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), 
      Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research 
      Institute of Hong Kong Polytechnic University, Shenzhen, 518057, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181001
PL  - China (Republic : 1949- )
TA  - J Food Drug Anal
JT  - Journal of food and drug analysis
JID - 101630927
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Humans
MH  - Illicit Drugs/*analysis/metabolism
MH  - Molecular Structure
MH  - Spectrometry, Mass, Electrospray Ionization
PMC - PMC9296206
OTO - NOTNLM
OT  - Body fluid
OT  - Drugs-of-abuse
OT  - ESI-MS
OT  - Quantitation
OT  - Wooden tips
COIS- Conflicts of interest The authors declare that there are no conflicts of 
      interest.
EDAT- 2019/04/17 06:00
MHDA- 2020/05/06 06:00
PMCR- 2018/10/01
CRDT- 2019/04/17 06:00
PHST- 2018/06/22 00:00 [received]
PHST- 2018/09/13 00:00 [revised]
PHST- 2018/09/13 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - j.jfda.2018.09.002 [pii]
AID - jfda-27-02-428 [pii]
AID - 10.1016/j.jfda.2018.09.002 [doi]
PST - ppublish
SO  - J Food Drug Anal. 2019 Apr;27(2):428-438. doi: 10.1016/j.jfda.2018.09.002. Epub 
      2018 Oct 1.