PMID- 30987786
OWN - NLM
STAT- MEDLINE
DCOM- 20190628
LR  - 20190628
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1599
DP  - 2019 Aug 16
TI  - In-situ derivatization and headspace solid-phase microextraction for gas 
      chromatography-mass spectrometry analysis of alkyl methylphosphonic acids 
      following solid-phase extraction using thin film.
PG  - 17-24
LID - S0021-9673(19)30364-4 [pii]
LID - 10.1016/j.chroma.2019.04.010 [doi]
AB  - A headspace solid-phase microextraction (HS-SPME) method, involving solid-phase 
      extraction and in-situ derivatization using polymeric thin film, was developed 
      for the gas chromatography-mass spectrometry (GC-MS) analysis of the degradation 
      products of nerve agents. The solid-phase extraction (SPE) was performed using 
      poly([2-(Methacryloyloxy)ethyl]trimethylammonium chloride) film on a gold plate 
      prepared via surface-initiated polymerization. The extracted analytes were 
      directly derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) on 
      the plate. Various parameters like fiber type, headspace time, temperature, and 
      amount of BSTFA were optimized. Under the optimized conditions, the relative 
      standard deviations (RSDs) were in the range 7.0-13.1% and the limits of 
      detection (LODs) were measured to be between 10 and 20 pg mL(-1). The application 
      of the developed method was tested using the 35th Organization for Prohibition of 
      Chemical Weapons (OPCW) proficiency test sample.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Kim, Hyunsuk
AU  - Kim H
AD  - Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 
      34141, South Korea; Chemical and Biological Defense Department, Agency for 
      Defense Development, Daejeon, 34186, South Korea.
FAU - Cho, Yungyeong
AU  - Cho Y
AD  - Chemical and Biological Defense Department, Agency for Defense Development, 
      Daejeon, 34186, South Korea.
FAU - Lee, Bong Soo
AU  - Lee BS
AD  - Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 
      34141, South Korea. Electronic address: leebongsoo@kaist.ac.kr.
FAU - Choi, Insung S
AU  - Choi IS
AD  - Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 
      34141, South Korea. Electronic address: ischoi@kaist.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20190408
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Nerve Agents)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Polymers)
RN  - 329W4YM10Z (methylphosphonic acid)
SB  - IM
MH  - Chemistry Techniques, Analytical/*methods
MH  - *Gas Chromatography-Mass Spectrometry
MH  - Limit of Detection
MH  - Nerve Agents/chemistry/isolation & purification
MH  - Organophosphorus Compounds/*analysis/chemistry
MH  - Polymers/*chemistry
MH  - *Solid Phase Microextraction/instrumentation
MH  - Temperature
OTO - NOTNLM
OT  - GC-MS
OT  - HS-SPME
OT  - In-situ derivative
OT  - Nerve agents
OT  - SI-ARGET ATRP
OT  - Solid-Phase extraction
EDAT- 2019/04/17 06:00
MHDA- 2019/06/30 06:00
CRDT- 2019/04/17 06:00
PHST- 2019/01/23 00:00 [received]
PHST- 2019/04/04 00:00 [revised]
PHST- 2019/04/06 00:00 [accepted]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2019/04/17 06:00 [entrez]
AID - S0021-9673(19)30364-4 [pii]
AID - 10.1016/j.chroma.2019.04.010 [doi]
PST - ppublish
SO  - J Chromatogr A. 2019 Aug 16;1599:17-24. doi: 10.1016/j.chroma.2019.04.010. Epub 
      2019 Apr 8.