PMID- 30988065
OWN - NLM
STAT- MEDLINE
DCOM- 20200701
LR  - 20221207
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 5
DP  - 2019 May 31
TI  - Associations between cytotoxic T-lymphocyte-associated antigen 4 gene 
      polymorphisms and diabetes mellitus: a meta-analysis of 76 case-control studies.
LID - BSR20190309 [pii]
LID - 10.1042/BSR20190309 [doi]
AB  - Background: Several genetic association studies already investigated potential 
      roles of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms 
      in diabetes mellitus (DM), with inconsistent results. Therefore, we performed 
      this meta-analysis to better assess the relationship between CTLA-4 gene 
      polymorphisms and DM in a larger pooled population.Methods: PubMed, Embase, Web 
      of Science, and CNKI were systematically searched for eligible studies. Pooled 
      odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate 
      the strength of associations between CTLA-4 gene polymorphisms and DM in all 
      possible genetic models.Results: A total of 76 studies were finally included in 
      our analyses. Significant associations with susceptibility to type 1 diabetes 
      mellitus (T1DM) were detected for rs231775 (dominant model: P=0.008, OR = 0.83, 
      95%CI 0.73-0.95; recessive model: P=0.003, OR = 1.27, 95%CI 1.09-1.50; allele 
      model: P=0.004, OR = 0.85, 95%CI 0.77-0.95) and rs5742909 (recessive model: 
      P=0.02, OR = 1.50, 95%CI 1.05-2.13) polymorphisms in overall population. Further 
      subgroup analyses revealed that rs231775 polymorphism was significantly 
      associated with susceptibility to T1DM in Caucasians and South Asians, and 
      rs5742909 polymorphism was significantly associated with susceptibility to T1DM 
      in South Asians. Moreover, rs231775 polymorphism was also found to be 
      significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) 
      in East Asians and South Asians.Conclusions: Our findings indicated that rs231775 
      and rs5742909 polymorphisms may serve as genetic biomarkers of T1DM, and rs231775 
      polymorphism may also serve as a genetic biomarker of T2DM.
CI  - (c) 2019 The Author(s).
FAU - Chen, Min
AU  - Chen M
AD  - Department of Internal Medicine, Ningbo No. 6 Hospital, Ningbo 315040, Zhejiang, 
      China lishumin9982@163.com.
FAU - Li, ShuMin
AU  - Li S
AUID- ORCID: 0000-0002-1858-4927
AD  - Department of Internal Medicine, Ningbo No. 6 Hospital, Ningbo 315040, Zhejiang, 
      China lishumin9982@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190515
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Asian People
MH  - CTLA-4 Antigen/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - White People
PMC - PMC6522704
OTO - NOTNLM
OT  - Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)
OT  - Diabetes mellitus (DM)
OT  - Gene polymorphisms
OT  - Meta-analysis
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/04/17 06:00
MHDA- 2020/07/02 06:00
PMCR- 2019/05/15
CRDT- 2019/04/17 06:00
PHST- 2019/02/01 00:00 [received]
PHST- 2019/04/02 00:00 [revised]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2020/07/02 06:00 [medline]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/05/15 00:00 [pmc-release]
AID - BSR20190309 [pii]
AID - 10.1042/BSR20190309 [doi]
PST - epublish
SO  - Biosci Rep. 2019 May 15;39(5):BSR20190309. doi: 10.1042/BSR20190309. Print 2019 
      May 31.