PMID- 30988377
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20231011
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Apr 15
TI  - Influence of childhood trauma and brain-derived neurotrophic factor Val66Met 
      polymorphism on posttraumatic stress symptoms and cortical thickness.
PG  - 6028
LID - 10.1038/s41598-019-42563-6 [doi]
LID - 6028
AB  - Interaction between childhood trauma and genetic factors influences the 
      pathophysiology of posttraumatic stress disorder (PTSD). This study examined the 
      interaction effect of childhood trauma and brain-derived neurotrophic factor 
      (BDNF) Val66Met polymorphism on PTSD symptoms and brain cortical thickness. A 
      total of 216 participants (133 healthy volunteers and 83 PTSD patients) were 
      recruited. T1-weighted structural magnetic resonance imaging, BDNF rs6265 
      genotyping through blood sampling, and clinical assessments including the 
      childhood trauma questionnaire (CTQ) and posttraumatic stress disorder Checklist 
      (PCL) were performed. A moderated regression analysis, two-way multivariate 
      analysis of covariance, and correlation analysis were conducted. An interaction 
      between the CTQ and the BDNF polymorphism significantly influenced PTSD symptom 
      severity. In fact, people with rs6265 Val/Val genotype and higher CTQ scores 
      showed higher PCL scores. Additionally, this interaction was significant on both 
      left fusiform and transverse temporal gyri thickness. Furthermore, the thickness 
      of both brain regions was significantly correlated with psychological symptoms 
      including depression, anxiety, rumination, and cognitive emotion regulation 
      methods; yet this was mainly observed in people with the Val/Val genotype. The 
      interaction between childhood trauma and BDNF polymorphism significantly 
      influences both PTSD symptoms and cortical thickness and the Val/Val genotype may 
      increase the risk in Korean population.
FAU - Jin, Min Jin
AU  - Jin MJ
AD  - Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, 
      Republic of Korea.
AD  - Department of Psychology, Chung-Ang University, Seoul, Republic of Korea.
FAU - Jeon, Hyeonjin
AU  - Jeon H
AD  - Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, 
      Republic of Korea.
FAU - Hyun, Myoung Ho
AU  - Hyun MH
AD  - Department of Psychology, Chung-Ang University, Seoul, Republic of Korea.
FAU - Lee, Seung-Hwan
AU  - Lee SH
AD  - Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, 
      Republic of Korea. lshpss@paik.ac.kr.
AD  - Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic 
      of Korea. lshpss@paik.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190415
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebellar Cortex/pathology
MH  - Child
MH  - Child Abuse
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Stress Disorders, Post-Traumatic/*etiology/*genetics/pathology
PMC - PMC6465240
COIS- The authors declare no competing interests.
EDAT- 2019/04/17 06:00
MHDA- 2020/10/08 06:00
PMCR- 2019/04/15
CRDT- 2019/04/17 06:00
PHST- 2018/11/16 00:00 [received]
PHST- 2019/03/29 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
PHST- 2019/04/15 00:00 [pmc-release]
AID - 10.1038/s41598-019-42563-6 [pii]
AID - 42563 [pii]
AID - 10.1038/s41598-019-42563-6 [doi]
PST - epublish
SO  - Sci Rep. 2019 Apr 15;9(1):6028. doi: 10.1038/s41598-019-42563-6.