PMID- 30988503
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201005
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 42
IP  - 10
DP  - 2019 Oct
TI  - Factors related to peripheral arterial disease in patients undergoing 
      hemodialysis: the potential role of monocyte chemoattractant protein-1.
PG  - 1528-1535
LID - 10.1038/s41440-019-0259-x [doi]
AB  - Peripheral arterial disease (PAD) is substantially prevalent among patients in 
      the end stage of renal disease (ESRD). We considered factors related to 
      peripheral arterial disease in patients undergoing hemodialysis including the 
      important role of monocyte chemoattractant protein-1 (MCP-1) serum 
      concentrations. We studied 150 patients in on-line-predilution hemodiafiltration. 
      Dialysis sufficiency was defined by Kt/V for urea. PAD was defined using clinical 
      criteria, ankle-brachial index and Doppler ultrasound in the lower limbs. MCP-1 
      serum concentrations were measured using enzyme-linked immunoabsorbed assay 
      (EpsilonLISA). We performed chi-square tests and logistic regression analysis to 
      investigate risk factors for the prevalence of PAD in these patients including 
      MCP-1 serum concentrations. The patients with manifested PAD had elevated MCP-1, 
      higher BP, higher arterial stiffness markers, higher markers of malnutrition, 
      uncontrolled metabolic acidosis, bone disease and lower obtained dialysis 
      adequacy than the patients without PAD. The association between PAD manifestation 
      and high MCP-1 was found significant (x(2) = 9.6, p = 0.001). The built logistic 
      regression analysis showed that the high MCP-1 increased the risk for PAD 3.2 
      (95% C.I 1.3-8.2) folds after adjustment for confounders. PAD was also 
      significantly associated with non-administration of vitamin D agents during 
      dialysis (x(2) = 3.5, p = 0.04).Malnutrition, low-grade inflammation mainly 
      defined by high MCP-1 serum concentrations, metabolic acidosis and bone disease 
      were included in significant predictors for peripheral arterial disease in 
      patients undergoing hemodiafiltration. The obtained dialysis sufficiency and the 
      therapy during dialysis sessions seem to play an additional role in the 
      demonstration of peripheral vascular disease in these patients.
FAU - Raikou, Vaia D
AU  - Raikou VD
AD  - 1st Department of Medicine - Propaedaetic, National & Kapodistrian University of 
      Athens, School of Medicine, Athens, Greece. vraikou@med.uoa.gr.
FAU - Kyriaki, Despina
AU  - Kyriaki D
AD  - Department of Nuclear Medicine, General Hospital "LAIotaKO", Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20190415
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - Aged
MH  - Chemokine CCL2/blood/*physiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Lipoproteins, HDL/blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/blood/*etiology
MH  - *Renal Dialysis
OTO - NOTNLM
OT  - Bone disease
OT  - Hemodiafiltration
OT  - Inflammation
OT  - MCP-1
OT  - Malnutrition
OT  - Peripheral arterial disease
OT  - Vitamin D
EDAT- 2019/04/17 06:00
MHDA- 2020/10/06 06:00
CRDT- 2019/04/17 06:00
PHST- 2018/10/23 00:00 [received]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/02/09 00:00 [revised]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2019/04/17 06:00 [entrez]
AID - 10.1038/s41440-019-0259-x [pii]
AID - 10.1038/s41440-019-0259-x [doi]
PST - ppublish
SO  - Hypertens Res. 2019 Oct;42(10):1528-1535. doi: 10.1038/s41440-019-0259-x. Epub 
      2019 Apr 15.