PMID- 30988637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Effects of polymorphism in FABP2 Ala54Thr on serum lipids and glycemic control in 
      low glycemic index diets are associated with gender among Han Chinese with type 2 
      diabetes mellitus.
PG  - 413-421
LID - 10.2147/DMSO.S196738 [doi]
AB  - BACKGROUND/AIMS: Low glycemic index (GI) diets may have beneficial effects on 
      glycemic control and serum lipid levels in patients with type 2 diabetes, but 
      whether its effect is affected by polymorphisms of genes associated with lipid 
      metabolism remains unclear. This study investigated whether the effects of a 
      low-GI diet on serum lipids and glycemic control in patients with diabetes are 
      associated with polymorphisms of FABP2 Ala54Thr (rs1799883). METHODS: A 
      retrospective study was conducted involving 165 patients with type 2 diabetes 
      mellitus (T2DM) who participated in two completed trials. Parameters reflecting 
      the glycemic control, inflammatory factors, and fasting plasma lipids before and 
      after intervention were measured, and the polymorphism of rs1799883 for each 
      participant was genotyped using a Mas-sARRAY. Differences between the genotypes 
      of rs1799883 before or after the intervention were compared, and changes in the 
      lipid profiles, glycemic control, inflammatory profiles, and dietary intake from 
      baseline were analyzed using an analysis of covariance (generalized linear 
      model). RESULTS: When the data were analyzed as a whole, after 4-5 weeks of 
      similar low-GI diet intervention, we found that the decrease of triglycerides 
      (TG) in the homozygous Ala54 carriers was more significant than that in the Thr54 
      allele carriers ([-0.58+/-1.24] vs [-0.14+/-1.08], P=0.015) with the adjustment for 
      potential confounding factors; furthermore, compared with the Thr54 carriers, 
      there was a significant trend in the decrease of total cholesterol (TC) in the 
      homozygous Ala54 carriers (P=0.057). Subgroup analysis revealed that in women the 
      homozygous Ala54 carriers exhibited a significant decrease of serum TG, TC, 
      fasting blood glucose, and glycated albumin in women, but this was not noted in 
      men. CONCLUSION: The effect of FABP2 Ala54Thr polymorphism on response to blood 
      lipids and gly-cemic control in low-GI diets is associated with gender among Han 
      Chinese patients with T2DM.
FAU - Liu, Peng Ju
AU  - Liu PJ
AD  - Departments of Clinical Nutrition, Peking Union Medical College Hospital, China 
      Academic Medical Science and Peking Union Medical College, Beijing, People's 
      Republic of China, liuyp1227@vip.sina.com; lpjjia@126.com.
FAU - Liu, Yan Ping
AU  - Liu YP
AD  - Departments of Clinical Nutrition, Peking Union Medical College Hospital, China 
      Academic Medical Science and Peking Union Medical College, Beijing, People's 
      Republic of China, liuyp1227@vip.sina.com; lpjjia@126.com.
FAU - Qin, Hui Kun
AU  - Qin HK
AD  - Department of Nutrition, Pinggu Hospital of Traditional Chinese Medicine, 
      Beijing, People's Republic of China.
FAU - Xing, Tong
AU  - Xing T
AD  - Department of Nutrition, Pinggu Hospital of Traditional Chinese Medicine, 
      Beijing, People's Republic of China.
FAU - Li, Shan Shan
AU  - Li SS
AD  - Departments of Clinical Nutrition, Peking Union Medical College Hospital, China 
      Academic Medical Science and Peking Union Medical College, Beijing, People's 
      Republic of China, liuyp1227@vip.sina.com; lpjjia@126.com.
FAU - Bao, Yuan Yuan
AU  - Bao YY
AD  - Departments of Clinical Nutrition, Peking Union Medical College Hospital, China 
      Academic Medical Science and Peking Union Medical College, Beijing, People's 
      Republic of China, liuyp1227@vip.sina.com; lpjjia@126.com.
LA  - eng
PT  - Journal Article
DEP - 20190327
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6441458
OTO - NOTNLM
OT  - fatty acid-binding protein 2
OT  - low glycemic index diet
OT  - plasma lipids
OT  - single-nucleotide polymorphism
OT  - type 2 diabetes mellitus
COIS- Disclosure The authors have no conflicts of interest to report in this work. The 
      authors alone are responsible for the content and writing of this paper.
EDAT- 2019/04/17 06:00
MHDA- 2019/04/17 06:01
PMCR- 2019/03/27
CRDT- 2019/04/17 06:00
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/04/17 06:01 [medline]
PHST- 2019/03/27 00:00 [pmc-release]
AID - dmso-12-413 [pii]
AID - 10.2147/DMSO.S196738 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Mar 27;12:413-421. doi: 10.2147/DMSO.S196738. 
      eCollection 2019.