PMID- 30988667
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 10
DP  - 2019
TI  - Effects of Childhood Maltreatment on Social Cognition and Brain Functional 
      Connectivity in Borderline Personality Disorder Patients.
PG  - 156
LID - 10.3389/fpsyt.2019.00156 [doi]
LID - 156
AB  - Borderline personality disorder (BPD) is a chronic condition characterized by 
      high levels of impulsivity, affective instability, and difficulty to establish 
      and manage interpersonal relationships. However, little is known about its 
      etiology and neurobiological substrates. In our study, we wanted to investigate 
      the influence of child abuse in the psychopathology of BPD by means of social 
      cognitive paradigms [the Movie for the Assessment of Social Cognition (MASC) and 
      the reading the mind in the eyes test (RMET)], and resting state functional 
      magnetic resonance imaging (rs-fMRI). For this, we recruited 33 participants, 18 
      BPD patients, and 15 controls. High levels of self-reported childhood 
      maltreatment were reported by BPD patients. For the sexual abuse subdimension, 
      there were no differences between the BPD and the control groups, but there was a 
      negative correlation between MASC scores and total childhood maltreatment levels, 
      as well as between physical abuse, physical negligence, and MASC. Both groups 
      showed that the higher the level of childhood maltreatment, the lower the 
      performance on the MASC social cognitive test. Further, in the BPD group, there 
      was hypoconnectivity between the structures responsible for emotion regulation 
      and social cognitive responses that have been described as part of the 
      frontolimbic circuitry (i.e., amygdala). Differential levels of connectivity, 
      associated with different types and levels of abuse were also observed.
FAU - Duque-Alarcon, Xochitl
AU  - Duque-Alarcon X
AD  - Clinica de Especialidades de Neuropsiquiatria, Instituto de Seguridad y Servicios 
      Sociales de los Trabajadores del Estado (ISSSTE), Mexico City, Mexico.
FAU - Alcala-Lozano, Ruth
AU  - Alcala-Lozano R
AD  - Departamento de Investigacion Clinica, Instituto Nacional de Psiquiatria Ramon de 
      la Fuente Muniz, Mexico City, Mexico.
FAU - Gonzalez-Olvera, Jorge J
AU  - Gonzalez-Olvera JJ
AD  - Departamento de Investigacion Clinica, Instituto Nacional de Psiquiatria Ramon de 
      la Fuente Muniz, Mexico City, Mexico.
FAU - Garza-Villarreal, Eduardo A
AU  - Garza-Villarreal EA
AD  - Departamento de Investigacion Clinica, Instituto Nacional de Psiquiatria Ramon de 
      la Fuente Muniz, Mexico City, Mexico.
AD  - MIND Lab, Center of Functionally Integrative Neuroscience, University of Aarhus, 
      Aarhus, Denmark.
FAU - Pellicer, Francisco
AU  - Pellicer F
AD  - Laboratorio de Neurofisiologia Integrativa, Instituto Nacional de Psiquiatria 
      Ramon de la Fuente Muniz, Mexico City, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20190329
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6452291
OTO - NOTNLM
OT  - borderline personality disorder
OT  - brain remodeling
OT  - childhood maltreatment
OT  - functional connectivity
OT  - social cognition
EDAT- 2019/04/17 06:00
MHDA- 2019/04/17 06:01
PMCR- 2019/03/29
CRDT- 2019/04/17 06:00
PHST- 2018/11/02 00:00 [received]
PHST- 2019/03/04 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/04/17 06:01 [medline]
PHST- 2019/03/29 00:00 [pmc-release]
AID - 10.3389/fpsyt.2019.00156 [doi]
PST - epublish
SO  - Front Psychiatry. 2019 Mar 29;10:156. doi: 10.3389/fpsyt.2019.00156. eCollection 
      2019.