PMID- 30988826
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 17
IP  - 5
DP  - 2019 May
TI  - Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal 
      squamous cell carcinoma.
PG  - 4717-4725
LID - 10.3892/ol.2019.10104 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of 
      head and neck malignancies. Advanced LSCC has failed to demonstrate a 
      satisfactory prognosis, despite the progresses in the diagnosis and treatment, 
      and the optimal treatment modality continues to be debated. To evaluate the 
      clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for 
      patients with resected advanced LSCC, a retrospective analysis of 232 patients 
      with LSCC who had undergone total laryngectomy and neck dissection between 2005 
      and 2010 was conducted. Of the 232 eligible patients, 167 patients (72%) received 
      surgery alone, whereas 65 patients (28%) received surgery + adjuvant CRT. In the 
      overall cohort, the 5- and 10-year overall survival (OS) rates were 55.2 and 
      48.3%, respectively. Multivariate analysis revealed that the clinical stage was 
      significantly associated with OS. However, the N classification was an 
      independent indicator in disease-free survival and laryngeal cancer-specific 
      survival. In those patients with stage IV disease, patients receiving adjuvant 
      CRT exhibited a markedly improved survival benefit compared with patients 
      receiving surgical treatment only, following propensity score matching of the 
      data (P<0.05). The application of adjuvant CRT confers additional survival 
      benefits in comparison with surgery-only treatment regimens for advanced LSCC. 
      However, additional prospective studies are required.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and 
      Throat Hospital of Fudan University, Shanghai 200031, P.R. China.
FAU - Deng, Weiye
AU  - Deng W
AD  - Departments of Radiation Oncology, The University of Texas Southwestern Medical 
      Center, Dallas, TX 75390, USA.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and 
      Throat Hospital of Fudan University, Shanghai 200031, P.R. China.
FAU - Li, Cai
AU  - Li C
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and 
      Throat Hospital of Fudan University, Shanghai 200031, P.R. China.
FAU - Wang, Yifan
AU  - Wang Y
AD  - Departments of Radiation Oncology, The University of Texas Southwestern Medical 
      Center, Dallas, TX 75390, USA.
FAU - Liu, Xiangyu
AU  - Liu X
AD  - Department of Biostatistics and Data Science, School of Public Health, The 
      University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and 
      Throat Hospital of Fudan University, Shanghai 200031, P.R. China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and 
      Throat Hospital of Fudan University, Shanghai 200031, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190304
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6447886
OTO - NOTNLM
OT  - chemoradiotherapy
OT  - laryngeal cancer
OT  - prognosis
OT  - squamous cell carcinoma
OT  - survival
EDAT- 2019/04/17 06:00
MHDA- 2019/04/17 06:01
PMCR- 2019/03/04
CRDT- 2019/04/17 06:00
PHST- 2018/01/27 00:00 [received]
PHST- 2019/01/25 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/04/17 06:01 [medline]
PHST- 2019/03/04 00:00 [pmc-release]
AID - OL-0-0-10104 [pii]
AID - 10.3892/ol.2019.10104 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 May;17(5):4717-4725. doi: 10.3892/ol.2019.10104. Epub 2019 Mar 
      4.