PMID- 30988967
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20220408
IS  - 2075-0528 (Electronic)
IS  - 2075-051X (Print)
IS  - 2075-051X (Linking)
VI  - 18
IP  - 4
DP  - 2018 Nov
TI  - Food Allergen Sensitisation Patterns in Omani Patients with Allergic 
      Manifestations.
PG  - e483-e488
LID - 10.18295/squmj.2018.18.04.009 [doi]
AB  - OBJECTIVES: This study aimed to evaluate the relationship between food allergen 
      sensitisation patterns and allergic manifestations in Omani patients and 
      highlight the importance of specific immunoglobulin E (IgE) testing. METHODS: 
      This retrospective study included all patients referred due to allergic 
      manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, 
      from November 2012 to November 2016. Specific IgE blood testing was performed to 
      determine sensitisation to common foods known to cause allergic reactions. 
      RESULTS: A total of 164 patients were referred to SQUH over the study period, 
      with 35.4% presenting with one allergic manifestation, 48.8% with 2-3 and 15.9% 
      presenting with more than three manifestations. There was a family history of 
      allergies in 70.7% of patients. Eosinophil counts and total and specific IgE 
      levels were elevated in 18.9%, 54.9% and 73.2% of patients, respectively. 
      Patients demonstrated sensitisation to cow milk (47.6%), wheat (41.5%), chicken 
      eggs (34.8%), mixed tree nuts (34.1%), lentils (33.5%), peanuts (32.9%), soy 
      (32.3%), shrimp (23.2%) and fish (15.2%). Overall, 19.5% were sensitised to a 
      single allergen, 14% were sensitised to 2-3 and 39.6% were sensitised to more 
      than three allergens. Almost one-third (29.3%) of patients suffered from 
      food-induced anaphylaxis, of which 85.4% were prescribed self-injectable 
      adrenaline. CONCLUSION: To the best of the authors' knowledge, this study is the 
      first to describe food allergen sensitisation patterns among Omani patients with 
      allergic manifestations. In conjunction with clinical symptoms, the correct 
      interpretation of specific IgE levels is important to diagnose food allergies and 
      make safe decisions about reintroducing foods.
FAU - Al-Tamemi, Salem
AU  - Al-Tamemi S
AD  - Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman.
FAU - Naseem, Shafiq-Ur-Rehman
AU  - Naseem SU
AD  - Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman.
FAU - Tufail-Alrahman, Munira
AU  - Tufail-Alrahman M
AD  - Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.
FAU - Al-Kindi, Mahmood
AU  - Al-Kindi M
AD  - Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.
FAU - Alshekaili, Jalila
AU  - Alshekaili J
AD  - Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.
LA  - eng
PT  - Journal Article
DEP - 20190328
PL  - Oman
TA  - Sultan Qaboos Univ Med J
JT  - Sultan Qaboos University medical journal
JID - 101519915
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Egg Hypersensitivity/epidemiology/therapy
MH  - Female
MH  - Food Hypersensitivity/epidemiology/*therapy
MH  - Humans
MH  - Hypersensitivity/complications/therapy
MH  - Immunization/*methods/*standards/statistics & numerical data
MH  - Immunoglobulin E/analysis/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Milk Hypersensitivity/epidemiology/therapy
MH  - Nut Hypersensitivity/epidemiology/therapy
MH  - Oman/epidemiology
MH  - Retrospective Studies
MH  - Wheat Hypersensitivity/epidemiology/therapy
PMC - PMC6443266
OTO - NOTNLM
OT  - Anaphylaxis
OT  - Asthma
OT  - Atopic Dermatitis
OT  - Food Allergies
OT  - Hypersensitivity
OT  - Immunoglobulin E
OT  - Oman
OT  - Urticaria
COIS- CONFLICT OF INTEREST The authors declare no conflicts of interest.
EDAT- 2019/04/17 06:00
MHDA- 2019/06/25 06:00
PMCR- 2018/11/01
CRDT- 2019/04/17 06:00
PHST- 2018/05/23 00:00 [received]
PHST- 2018/09/16 00:00 [revised]
PHST- 2018/10/04 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - squmj1811-e483-488 [pii]
AID - 10.18295/squmj.2018.18.04.009 [doi]
PST - ppublish
SO  - Sultan Qaboos Univ Med J. 2018 Nov;18(4):e483-e488. doi: 
      10.18295/squmj.2018.18.04.009. Epub 2019 Mar 28.