PMID- 30989332
OWN - NLM
STAT- MEDLINE
DCOM- 20200103
LR  - 20200309
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 39
IP  - 6
DP  - 2019 Jun
TI  - Discordance between doctor and patient assessments and non-adherence to 
      subcutaneous biological drugs.
PG  - 1077-1082
LID - 10.1007/s00296-019-04304-w [doi]
AB  - To estimate the agreement level between patient and physician assessment of 
      disease activity and to explore whether agreement is associated with adherence to 
      subcutaneous (SC) biological drugs in rheumatoid arthritis (RA). Cross-sectional 
      study of RA patients who had been prescribed a SC biological drug in the past 
      12-18 months was performed. Patients and physicians global disease activity on 
      visual analogue scale (VAS) were collected. Disagreement was defined as an 
      absolute difference >/= 3 points between VAS scores. Adherence was assessed by the 
      Medication Possession Ratio (MPR), considering adherence an MPR > 80%. We 
      analysed 360 patients of whom 15.5% presented disagreement with their physicians. 
      The mean patient global VAS was 5.75 +/- 1.8 (median 5.5 [5-7]) in the disagreement 
      group versus 2.7 +/- 2.2 (median 2 [1-4]) in the agreement group (p < 0.001). There 
      were also differences in physicians global VAS between groups (p = 0.01). The 
      non-adherence to SC biological drugs rate was 10.7% and 14.5% in the disagreement 
      and agreement groups (p = 0.45). No association between adherence and discordance 
      was found. Disagreement in the global disease activity between patients and 
      physicians was detected in 15.5% of patients. In general, patients perceived 
      higher disease activity. No associations between patient-physician disagreement 
      in VAS and adherence were observed.
FAU - Oton, Teresa
AU  - Oton T
AUID- ORCID: 0000-0003-3622-7146
AD  - Instituto de Salud Musculoesqueletica (Inmusc), Calle Conde de la Cimera, 6, 
      28040, Madrid, Spain. teresa.oton@inmusc.eu.
FAU - Carmona, Loreto
AU  - Carmona L
AUID- ORCID: 0000-0002-4401-2551
AD  - Instituto de Salud Musculoesqueletica (Inmusc), Calle Conde de la Cimera, 6, 
      28040, Madrid, Spain.
FAU - Urruticoechea-Arana, Ana
AU  - Urruticoechea-Arana A
AUID- ORCID: 0000-0001-8290-1846
AD  - Servicio de Reumatologia, Hospital Can Misses, Ibiza, Spain.
FAU - Calvo-Alen, Jaime
AU  - Calvo-Alen J
AUID- ORCID: 0000-0001-9378-8412
AD  - Servicio de Reumatologia, Hospital Universitario Araba, Vitoria, Spain.
FAU - Arteaga, Maria J
AU  - Arteaga MJ
AD  - Medical Affairs, Merck Sharp & Dohme S.A, Madrid, Spain.
FAU - Cea-Calvo, Luis
AU  - Cea-Calvo L
AD  - Medical Affairs, Merck Sharp & Dohme S.A, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190416
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antirheumatic Agents/*administration & dosage/therapeutic use
MH  - Arthritis, Rheumatoid/*drug therapy/physiopathology
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Logistic Models
MH  - Male
MH  - Medication Adherence/*statistics & numerical data
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Patient Reported Outcome Measures
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Visual Analog Scale
OTO - NOTNLM
OT  - Adherence
OT  - Biological drugs
OT  - Compliance
OT  - Discordance
OT  - Disease activity
OT  - Patient perspective
EDAT- 2019/04/17 06:00
MHDA- 2020/01/04 06:00
CRDT- 2019/04/17 06:00
PHST- 2019/02/21 00:00 [received]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2020/01/04 06:00 [medline]
PHST- 2019/04/17 06:00 [entrez]
AID - 10.1007/s00296-019-04304-w [pii]
AID - 10.1007/s00296-019-04304-w [doi]
PST - ppublish
SO  - Rheumatol Int. 2019 Jun;39(6):1077-1082. doi: 10.1007/s00296-019-04304-w. Epub 
      2019 Apr 16.