PMID- 30989925
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 44
IP  - 3
DP  - 2019 Feb
TI  - [Dynamic chromatopharmacokinetics model for components in Chinese medicine and 
      validation in Buyang Huanwu Decoction].
PG  - 574-581
LID - 10.19540/j.cnki.cjcmm.20180925.005 [doi]
AB  - The Chinese medicine is mostly derived from plants or animals, highly 
      polymorphic, with dynamic components which are reflected by the characteristic 
      peaks and fingerprint peaks in chromatographic fingerprints. The 
      chromatopharmacokinetics method for determined components is not applicable due 
      to dynamic changes of chromatopharmacokinetics. Based on the preliminary study, 
      dynamic pharmacokinetics mathematical model for multiple components in Chinese 
      medicine was set up and verified by Buyang Huanwu Decoction as the model drug, 
      applying the principle of the total quantum statistical moment(TQSM), 
      superimposing or subtracting the relevant statistical parameters in blood samples 
      and blank samples. This provided a new method for the chromatopharmacokinetic 
      study of Chinese medicine. HPLC was used to determine the TQSM parameters in 
      blood and blank sample fingerprints of Buyang Huanwu Decoction at each point, and 
      the overall TQSM parameters of drug-containing blood sample and blank samples 
      were obtained with addition calculation of TQSM; while the initial TQSM of the 
      pure drug can be obtained with subtraction calculation. The metabolic and 
      absorption equilibrium constants were calculated iteratively to a steady state 
      using the estimated metabolic equilibrium constants, then the metabolic 
      chromatopharmacokinetic parameters in rats were obtained: VUC_T 1.262x10~8 mAu.s, 
      MRT_T 37.48 h, VRT_T 9.016x10~2 h~2, CL_T 25.79 mL.h~(-1).kg~(-1), Vs 1.586x10~2 
      mL.kg~(-1), t_(T,0.5) 6.15 h, respectively. This suggested that 95% of the 
      compounds in whole recipe were metabolized and secreted from the body after 
      0-96.33 h. The experiment verified that the established mathematical model and 
      the total quantum moment statistics parameters can represent the dose-time 
      relationship of Buyang Huanwu Decoction, which can be used to study on in vivo 
      metabolism dynamics for Chinese medicine.
FAU - Xiao, Mei-Feng
AU  - Xiao MF
AD  - College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China 
      Hunan Provincial Key Laboratory of Drugability and Preparation Modification of 
      Traditional Chinese Medicine Changsha 410208, China.
FAU - Duan, Xiao-Peng
AU  - Duan XP
AD  - College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China 
      Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese 
      Materia Medica, Hunan University of Chinese Medicine Changsha 410208, China.
FAU - Deng, Kai-Wen
AU  - Deng KW
AD  - The First Affinity Hospital, Hunan University of Chinese Medicine Changsha 
      410007, China.
FAU - Yang, Yan-Tao
AU  - Yang YT
AD  - College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China 
      Hunan Provincial Key Laboratory of Drugability and Preparation Modification of 
      Traditional Chinese Medicine Changsha 410208, China Supramolecular Mechanism and 
      Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University 
      of Chinese Medicine Changsha 410208, China.
FAU - Liu, Wen-Long
AU  - Liu WL
AD  - College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China 
      Hunan Provincial Key Laboratory of Drugability and Preparation Modification of 
      Traditional Chinese Medicine Changsha 410208, China Supramolecular Mechanism and 
      Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University 
      of Chinese Medicine Changsha 410208, China.
FAU - He, Fu-Yuan
AU  - He FY
AD  - College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China 
      Hunan Provincial Key Laboratory of Drugability and Preparation Modification of 
      Traditional Chinese Medicine Changsha 410208, China Supramolecular Mechanism and 
      Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University 
      of Chinese Medicine Changsha 410208, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (buyang huanwu)
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Drugs, Chinese Herbal/*pharmacokinetics
MH  - Rats
OTO - NOTNLM
OT  - Buyang Huanwu Decoction
OT  - chromatographic fingerprint
OT  - chromatopharmacokinetic
OT  - dynamic Chinese medicine
OT  - mathematics model
OT  - supermolecule
OT  - total quantum statistical moment
EDAT- 2019/04/17 06:00
MHDA- 2019/08/09 06:00
CRDT- 2019/04/17 06:00
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20180925.005 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):574-581. doi: 
      10.19540/j.cnki.cjcmm.20180925.005.