PMID- 30990137
OWN - NLM
STAT- MEDLINE
DCOM- 20190521
LR  - 20190521
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 59
IP  - 3
DP  - 2019 Apr 12
TI  - [Single Pill Indapamide and Perindopril Arginine Combination: Optimal Coupling of 
      Vascular Protection and Hemodynamic Risk Factors Reduction in Patients with 
      Essential Arterial Hypertension].
PG  - 18-26
LID - 10.18087/cardio.2019.3.10236 [doi]
AB  - OBJECTIVE: to investigate the impact of indapamide / perindopril single-pill 
      combination (I / P SPC) on arterial stiffness parameters, blood pressure (BP) 
      level and BP variability (BPV) in middle-aged patients with stage II grade 1-2 
      essential arterial hypertension (EAH). Materials and methods. We retrospectively 
      formed a group of patients with stage II grade 1-2 EAH who had not previously 
      received regular antihypertensive therapy (AHT) (n=52, mean age 52.9+/-6.0 years). 
      All patients were treated with I / P SPC and all of them achieved target office 
      BP level (less than 140 / 90 mm Hg). After 12 weeks of follow-up (from the time 
      of reaching the target BP) assessment of AHT effectiveness (general clinical 
      data, ambulatory blood pressure monitoring [ABPM], volume sphygmography, 
      echocardiography), and vascular stiffness evaluation were performed. RESULTS: At 
      the end of follow-up office systolic BP (SBP), diastolic BP (DBP), pulse 
      BP, day-time, night-time and 24‑hour SBP and DBP significantly (p<0.001 for 
      all) decreased. According to the ABPM data day-time, nighttime, and 24‑hour 
      systolic BPV significantly decreased (p=0.029, p=0.006 and p<0.001, 
      respectively); day-time and 24‑hour diastolic BPV also significantly decreased 
      (p=0.001 and p<0.001, respectively). Day-night standard deviation (SDdn) 
      significantly decreased too (p=0.002 and p<0.001, respectively). Volumetric 
      sphygmography showed significant decrease of right cardio-ankle vascular 
      index (CAVI) (from 8.20+/-1.29 to 7.58+/-1.44, p=0.001) and of left CAVI (from 
      8.13+/-1.40 to 7.46+/-1.43, p<0.001), as well as reduction of the number o f 
      patients with a right- and / or left-CAVI >9.0 (from 32.7 to 11.5 %, p=0.018). 
      According to assessment of arterial stiffness using the Vasotens24 software 
      package, the arterial stiffness index (ASI) significantly (p<0.001) decreased 
      from 153.5+/-29.9 to 138.3+/-20.0 (by -9.2+/-13.1 %). Transthoracic echocardiography 
      data demonstrated significant decrease (p<0.001) in effective arterial 
      elastance (from 1.82+/-0.43 to 1.58+/-0.36 mm Hg; by -11.85+/-16.29 %) and significant 
      (p<0.001) increase in the arterial compliance - from 1.27+/-0.34 to 1.54+/-0.38 mm 
      Hg / ml (+26.95+/-38.06 %). CONCLUSION: In AHT naive patients 40-65 years old with 
      stage II grade 1-2 EAH therapy with I / P SPC provided effective 24‑hour BP 
      control, reduced BPV and improved arterial stiffness parameters.
FAU - Borisova, E V
AU  - Borisova EV
AD  - A. I. Yevdokimov Moscow State University of Medicine and Dentistry City Clinical 
      Hospital named after E. O. Mukhin.
FAU - Kochetkov, A I
AU  - Kochetkov AI
AD  - A. I. Yevdokimov Moscow State University of Medicine and Dentistry.
FAU - Ostroumova, O D
AU  - Ostroumova OD
AD  - A. I. Yevdokimov Moscow State University of Medicine and Dentistry Sechenov First 
      Moscow State Medical University (Sechenov University).
LA  - rus
PT  - Journal Article
DEP - 20190412
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 0 (Antihypertensive Agents)
RN  - 94ZLA3W45F (Arginine)
RN  - F089I0511L (Indapamide)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - Antihypertensive Agents
MH  - Arginine
MH  - Blood Pressure
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Humans
MH  - *Hypertension/drug therapy
MH  - Indapamide/*therapeutic use
MH  - Middle Aged
MH  - Perindopril/*therapeutic use
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2019/04/17 06:00
MHDA- 2019/05/22 06:00
CRDT- 2019/04/17 06:00
PHST- 2019/04/12 00:00 [received]
PHST- 2019/04/12 00:00 [accepted]
PHST- 2019/04/17 06:00 [entrez]
PHST- 2019/04/17 06:00 [pubmed]
PHST- 2019/05/22 06:00 [medline]
AID - 10.18087/cardio.2019.3.10236 [doi]
PST - epublish
SO  - Kardiologiia. 2019 Apr 12;59(3):18-26. doi: 10.18087/cardio.2019.3.10236.