PMID- 30991621
OWN - NLM
STAT- MEDLINE
DCOM- 20200121
LR  - 20200309
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 22
DP  - 2019
TI  - Default mode network connectivity is associated with long-term clinical outcome 
      in patients with schizophrenia.
PG  - 101805
LID - S2213-1582(19)30155-X [pii]
LID - 10.1016/j.nicl.2019.101805 [doi]
LID - 101805
AB  - This study investigated whether resting-state functional connectivity is 
      associated with long-term clinical outcomes of patients with schizophrenia. 
      Resting-state brain images were obtained from 79 outpatients with schizophrenia 
      and 30 healthy controls (HC), using a 3 T-MRI scanner. All patients were 
      20-50 years old with >3 years' duration of illness and appeared clinically 
      stable. We assessed their psychopathology using the 18-item Brief Psychiatric 
      Rating Scale (BPRS-18) and divided them into "good," "moderate," and "poor" 
      outcome (SZ-GO, SZ-MO, and SZ-PO) groups depending on BPRS-18 total score. We 
      obtained individual functional connectivity maps between a seed region of the 
      bilateral posterior cingulate cortex (PCC) and all other brain regions and 
      compared the functional connectivity of the default mode network (DMN) among the 
      HC and 3 schizophrenia outcome groups, with a voxel-wise threshold of P < .001 
      within a cluster-extent threshold of 114 voxels. Additionally, we assessed 
      correlations between functional connectivity and BPRS-18 scores. The SZ-MO and 
      SZ-PO groups showed decreased functional connectivity between PCC and right 
      ventromedial prefrontal cortex (vmPFC), left middle cingulate cortex, and left 
      frontopolar cortex (FPC) compared to the SZ-GO and HC groups. DMN connectivity in 
      the right vmPFC and left FPC negatively correlated with subscale scores of the 
      BPRS-18, except the negative symptoms subscale. In this study, poorer clinical 
      outcomes in patients with schizophrenia were associated with decreased DMN 
      connectivity. In particular, the decreased functional connectivity might be 
      related to the severity of positive and mood symptoms rather than negative 
      symptoms.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Lee, Hyeongrae
AU  - Lee H
AD  - Department of Mental Health Research, National Center for Mental Health, Seoul, 
      Republic of Korea.
FAU - Lee, Dong-Kyun
AU  - Lee DK
AD  - Department of Mental Health Research, National Center for Mental Health, Seoul, 
      Republic of Korea.
FAU - Park, Kyeongwoo
AU  - Park K
AD  - Department of Mental Health Research, National Center for Mental Health, Seoul, 
      Republic of Korea.
FAU - Kim, Chul-Eung
AU  - Kim CE
AD  - Mental Health Research Institute, National Center for Mental Health, Seoul, 
      Republic of Korea.
FAU - Ryu, Seunghyong
AU  - Ryu S
AD  - Department of Mental Health Research, National Center for Mental Health, Seoul, 
      Republic of Korea. Electronic address: seunghyongryu@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190401
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Adult
MH  - *Connectome
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - *Outcome Assessment, Health Care
MH  - Prefrontal Cortex/diagnostic imaging/*physiopathology
MH  - Schizophrenia/diagnostic imaging/*physiopathology
MH  - *Severity of Illness Index
PMC - PMC6451190
OTO - NOTNLM
OT  - Default mode network
OT  - Functional connectivity
OT  - Outcome
OT  - Resting-state
OT  - Schizophrenia
EDAT- 2019/04/18 06:00
MHDA- 2020/01/22 06:00
PMCR- 2019/04/01
CRDT- 2019/04/18 06:00
PHST- 2018/12/14 00:00 [received]
PHST- 2019/03/17 00:00 [revised]
PHST- 2019/03/30 00:00 [accepted]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2020/01/22 06:00 [medline]
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - S2213-1582(19)30155-X [pii]
AID - 101805 [pii]
AID - 10.1016/j.nicl.2019.101805 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2019;22:101805. doi: 10.1016/j.nicl.2019.101805. Epub 2019 Apr 
      1.