PMID- 30992126
OWN - NLM
STAT- MEDLINE
DCOM- 20190521
LR  - 20200309
IS  - 1879-2596 (Electronic)
IS  - 0167-4889 (Print)
IS  - 0167-4889 (Linking)
VI  - 1865
IP  - 11 Pt B
DP  - 2018 Nov
TI  - Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma 
      gondii.
PG  - 1846-1856
LID - S0167-4889(18)30250-7 [pii]
LID - 10.1016/j.bbamcr.2018.08.004 [doi]
AB  - Toxoplasma gondii has a complex life cycle involving different hosts and is 
      dependent on fast responses, as the parasite reacts to changing environmental 
      conditions. T. gondii causes disease by lysing the host cells that it infects and 
      it does this by reiterating its lytic cycle, which consists of host cell 
      invasion, replication inside the host cell, and egress causing host cell lysis. 
      Calcium ion (Ca(2+)) signaling triggers activation of molecules involved in the 
      stimulation and enhancement of each step of the parasite lytic cycle. Ca(2+) 
      signaling is essential for the cellular and developmental changes that support T. 
      gondii parasitism. The characterization of the molecular players and pathways 
      directly activated by Ca(2+) signaling in Toxoplasma is sketchy and incomplete. 
      The evolutionary distance between Toxoplasma and other eukaryotic model systems 
      makes the comparison sometimes not informative. The advent of new genomic 
      information and new genetic tools applicable for studying Toxoplasma biology is 
      rapidly changing this scenario. The Toxoplasma genome reveals the presence of 
      many genes potentially involved in Ca(2+) signaling, even though the role of most 
      of them is not known. The use of Genetically Encoded Calcium Indicators (GECIs) 
      has allowed studies on the role of novel calcium-related proteins on egress, an 
      essential step for the virulence and dissemination of Toxoplasma. In addition, 
      the discovery of new Ca(2+) players is generating novel targets for drugs, 
      vaccines, and diagnostic tools and a better understanding of the biology of these 
      parasites.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hortua Triana, Miryam Andrea
AU  - Hortua Triana MA
AD  - Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, 
      GA 30602, USA.
FAU - Marquez-Nogueras, Karla M
AU  - Marquez-Nogueras KM
AD  - Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, 
      GA 30602, USA.
FAU - Vella, Stephen A
AU  - Vella SA
AD  - Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, 
      GA 30602, USA.
FAU - Moreno, Silvia N J
AU  - Moreno SNJ
AD  - Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, 
      GA 30602, USA; Department of Cellular Biology, University of Georgia, Athens, GA 
      30602, USA. Electronic address: smoreno@uga.edu.
LA  - eng
GR  - R01 AI096836/AI/NIAID NIH HHS/United States
GR  - R01 AI128356/AI/NIAID NIH HHS/United States
GR  - T32 AI060546/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180810
PL  - Netherlands
TA  - Biochim Biophys Acta Mol Cell Res
JT  - Biochimica et biophysica acta. Molecular cell research
JID - 101731731
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Protozoan Proteins)
RN  - EC 2.7.10.2 (Focal Adhesion Kinase 2)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/*metabolism
MH  - *Calcium Signaling
MH  - Calcium-Binding Proteins/metabolism
MH  - Disease Susceptibility
MH  - Focal Adhesion Kinase 2/metabolism
MH  - Life Cycle Stages
MH  - Protozoan Proteins/biosynthesis
MH  - Toxoplasma/*physiology
MH  - Toxoplasmosis/*metabolism/*parasitology
PMC - PMC6477927
MID - NIHMS1505792
OTO - NOTNLM
OT  - Calcium binding proteins
OT  - Calcium dependent protein kinases
OT  - Calcium signaling
OT  - Lytic cycle
OT  - Pathogenicity
OT  - Toxoplasma gondii
EDAT- 2019/04/18 06:00
MHDA- 2019/05/22 06:00
PMCR- 2019/11/01
CRDT- 2019/04/18 06:00
PHST- 2018/04/15 00:00 [received]
PHST- 2018/08/06 00:00 [revised]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2019/05/22 06:00 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - S0167-4889(18)30250-7 [pii]
AID - 10.1016/j.bbamcr.2018.08.004 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1846-1856. doi: 
      10.1016/j.bbamcr.2018.08.004. Epub 2018 Aug 10.