PMID- 30992391
OWN - NLM
STAT- MEDLINE
DCOM- 20200610
LR  - 20200610
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 5
DP  - 2019 May 31
TI  - SOX21-AS1 is associated with clinical stage and regulates cell proliferation in 
      nephroblastoma.
LID - BSR20190602 [pii]
LID - 10.1042/BSR20190602 [doi]
AB  - LncRNA SOX21 antisense RNA 1 (SOX21-AS1) dysregulated in many types of human 
      cancer, and functioned as tumor suppressor or promoter depending on tumor types. 
      However, there was no report about the role of SOX21-AS1 in nephroblastoma. In 
      the present study, we first found that SOX21-AS1 expression was elevated in 
      nephroblastoma tissues and cell lines compared with adjacent normal tissues and 
      normal human embryonic kidney cell line, respectively. Moreover, we observed 
      nephroblastoma patients with large tumor size, advanced National Wilms Tumor 
      Study (NWTS) stage or unfavorable histopathological type, and patients that had 
      higher SOX21-AS1 expression levels than nephroblastoma patients with small tumor 
      size, early NWTS stage or favorable histopathological type. The in vitro studies 
      suggested that knockdown of SOX21-AS1 suppressed nephroblastoma cell 
      proliferation and colony formation, and induced cell-cycle arrest through 
      up-regulating p57 expression. In conclusion, our study suggests that SOX21-AS1 
      functions as oncogenic lncRNA in nephroblastoma, which may provide a novel 
      insight for nephroblastoma carcinogenesis.
CI  - (c) 2019 The Author(s).
FAU - Zhang, Jingxiu
AU  - Zhang J
AD  - Department of Pediatrics, Linyi Central Hospital, Linyi, Shandong 276400, China.
FAU - Hou, Tianzhao
AU  - Hou T
AUID- ORCID: 0000-0001-8348-6197
AD  - Department of Surgery, Maternal and Child Health Care Family Planning Service 
      Center of Yishui County, Linyi, Shandong 276400, China houtianzhaoly@126.com.
FAU - Qi, Xueliang
AU  - Qi X
AD  - Department of Pediatrics, Linyi Central Hospital, Linyi, Shandong 276400, China.
FAU - Wang, Jihong
AU  - Wang J
AD  - Department of Pediatrics, Linyi Central Hospital, Linyi, Shandong 276400, China.
FAU - Sun, Xiangguo
AU  - Sun X
AD  - Department of Pediatrics, Linyi Central Hospital, Linyi, Shandong 276400, China.
LA  - eng
PT  - Journal Article
DEP - 20190517
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (SOX21 protein, human)
RN  - 0 (SOXB2 Transcription Factors)
SB  - IM
MH  - Carcinogenesis/genetics/pathology
MH  - Cell Cycle Checkpoints/genetics
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/*genetics
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - HEK293 Cells
MH  - Humans
MH  - Kidney Neoplasms/*genetics/pathology
MH  - Prognosis
MH  - Promoter Regions, Genetic/genetics
MH  - SOXB2 Transcription Factors/*genetics
MH  - Up-Regulation/genetics
MH  - Wilms Tumor/*genetics/pathology
PMC - PMC6522742
OTO - NOTNLM
OT  - SOX21-AS1
OT  - Wilms tumor
OT  - biomarker
OT  - lncRNA
OT  - nephroblastoma
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/04/18 06:00
MHDA- 2020/06/11 06:00
PMCR- 2019/05/17
CRDT- 2019/04/18 06:00
PHST- 2019/03/12 00:00 [received]
PHST- 2019/03/30 00:00 [revised]
PHST- 2019/04/02 00:00 [accepted]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2020/06/11 06:00 [medline]
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/05/17 00:00 [pmc-release]
AID - BSR20190602 [pii]
AID - 10.1042/BSR20190602 [doi]
PST - epublish
SO  - Biosci Rep. 2019 May 17;39(5):BSR20190602. doi: 10.1042/BSR20190602. Print 2019 
      May 31.