PMID- 30992679
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 12
DP  - 2019
TI  - Nonsurgical integrative inpatient treatments for symptomatic lumbar spinal 
      stenosis: a multi-arm randomized controlled pilot trial.
PG  - 1103-1113
LID - 10.2147/JPR.S173178 [doi]
AB  - BACKGROUND: Lumbar spinal stenosis (LSS) is a chronic condition that causes low 
      back pain and neurogenic claudication, often resulting in significant limitation 
      of daily activities. In this open-label randomized controlled pilot study, we 
      assessed the safety and feasibility of 4-week novel integrative inpatient 
      treatments for LSS. METHODS: Thirty-six symptomatic LSS patients were randomly 
      and equally allocated to one of the three groups: Mokhuri Chuna treatment 1 (MT1) 
      group, Mokhuri Chuna treatment 2 (MT2) group, or conventional management 
      treatment (CMT) group. MT1 patients were treated with herbal medication, Mokhuri 
      Chuna, and acupuncture, and received daily physician consultation; MT2 patients 
      were treated with Mokhuri Chuna and acupuncture without any herbal medication, 
      and received daily physician consultation; and CMT patients received conventional 
      pain management therapy that included epidural steroid injection, oral NSAID, and 
      muscle relaxant medication, along with daily physiotherapy. The primary outcome 
      of this pilot study was safety as measured by the type and incidence of adverse 
      events (AEs). The secondary outcome measures included VAS score for low back pain 
      and leg pain, Oswestry Disability Index, Oxford Claudication Score (OCS), walking 
      capacity on a 50 m flat track and treadmill, and EuroQol-5D score. Magnetic 
      resonance imaging was also performed up to 6 months after treatment cessation. 
      RESULTS: Thirty-four treated patients were included in the analysis, based on the 
      modified intention-to-treat principle. No serious AEs were observed or reported. 
      Compared to the CMT group, the MT1 and MT2 groups did show significant 
      improvement at 3 and 6 months in various domains, including pain (VAS score for 
      leg and back pain) and function (OCS and treadmill walking). CONCLUSION: These 
      novel multimodal integrative treatments for LSS are both clinically safe and 
      logistically feasible. Larger, adequately powered randomized controlled trials 
      will be necessary to assess comparative efficacy and thoroughly analyze the 
      cost-effectiveness of each treatment approach. CLINICAL TRIAL REGISTRATION NUMBER 
      CRIS: KCT0001218.
FAU - Kim, Kiok
AU  - Kim K
AD  - Department of Spine Center, Mokhuri Neck & Back Hospital, Seoul, South Korea.
FAU - Shin, Kyung-Min
AU  - Shin KM
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South 
      Korea.
FAU - Hunt, Christy L
AU  - Hunt CL
AD  - Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, 
      USA.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, 
      Mayo Clinic, Rochester, MN, USA.
FAU - Bauer, Brent A
AU  - Bauer BA
AD  - Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
FAU - Kwon, Ojin
AU  - Kwon O
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South 
      Korea.
FAU - Lee, Jun-Hwan
AU  - Lee JH
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South 
      Korea.
AD  - Korean Medicine Life Science, Campus of Korea Institute of Oriental Medicine, 
      University of Science & Technology (UST), Daejeon, South Korea.
FAU - Seo, Bok-Nam
AU  - Seo BN
AD  - Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South 
      Korea.
FAU - Jung, So-Young
AU  - Jung SY
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South 
      Korea.
FAU - Youn, Yousuk
AU  - Youn Y
AD  - Department of Spine Center, Mokhuri Neck & Back Hospital, Seoul, South Korea.
FAU - Lee, Sang Ho
AU  - Lee SH
AD  - Department of Spine Center, Mokhuri Neck & Back Hospital, Seoul, South Korea.
FAU - Choi, Jung Chul
AU  - Choi JC
AD  - Department of Spine Center, Mokhuri Neck & Back Hospital, Seoul, South Korea.
FAU - Jung, Jae Eun
AU  - Jung JE
AD  - Hongik Neurosurgery Hospital, Seongnam, South Korea.
FAU - Kim, Jaehong
AU  - Kim J
AD  - Department of Spine Center, Mokhuri Neck & Back Hospital, Seoul, South Korea.
FAU - Qu, Wenchun
AU  - Qu W
AD  - Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, 
      USA.
AD  - Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic, Rochester, 
      MN, USA, Eldrige.jason@mayo.edu.
FAU - Kim, Tae-Hun
AU  - Kim TH
AD  - Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee 
      University, Seoul, South Korea.
FAU - Eldrige, Jason S
AU  - Eldrige JS
AD  - Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic, Rochester, 
      MN, USA, Eldrige.jason@mayo.edu.
LA  - eng
PT  - Journal Article
DEP - 20190328
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC6445233
OTO - NOTNLM
OT  - Chuna
OT  - acupuncture
OT  - complementary and alternative medicine
OT  - epidural steroid injection
OT  - low back pain
OT  - lumbar spinal stenosis
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2019/04/18 06:00
MHDA- 2019/04/18 06:01
PMCR- 2019/03/28
CRDT- 2019/04/18 06:00
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2019/04/18 06:01 [medline]
PHST- 2019/03/28 00:00 [pmc-release]
AID - jpr-12-1103 [pii]
AID - 10.2147/JPR.S173178 [doi]
PST - epublish
SO  - J Pain Res. 2019 Mar 28;12:1103-1113. doi: 10.2147/JPR.S173178. eCollection 2019.