PMID- 30993081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 8
DP  - 2019
TI  - Possible Role of Cyclic AMP Response Element Binding/Brain-Derived Neurotrophic 
      Factor Signaling Pathway in Mediating the Pharmacological Effects of Duloxetine 
      against Methamphetamine Use-Induced Cognitive Impairment and Withdrawal-Induced 
      Anxiety and Depression in Rats.
PG  - 11
LID - 10.4103/abr.abr_34_18 [doi]
LID - 11
AB  - BACKGROUND: Duloxetine is used for treating depression and anxiety. The current 
      study evaluated the effects of duloxetine against methamphetamine 
      withdrawal-induced anxiety, depression, and motor disturbances and 
      methamphetamine use-induced cognitive impairments. MATERIALS AND METHODS: 
      Ninety-six adult male rats were used for two independent experiments. Each 
      experiment consisted of Groups 1 and 2 which received normal saline (0.2 ml/rat) 
      and methamphetamine (10 mg/kg) respectively, Groups 3, 4, and 5 received both 
      methamphetamine and duloxetine at doses of 5, 10, and 15 mg/kg, respectively. 
      Groups 6, 7, and 8 received 5, 10, and 15 mg/kg of duloxetine, respectively. All 
      administrations were performed for 21 days. In experiment 1, elevated plus maze 
      (EPM), open-field test (OFT), forced swim test (FST), and tail suspension test 
      (TST) were used to examine anxiety and depression in animals during withdrawal 
      period. In experiment 2, Morris water maze (MWM) test was used to assess the 
      effect of methamphetamine use followed by duloxetine treatment, on learning and 
      memory. In the experiments, the expression of cyclic AMP response element binding 
      (CREB) and brain-derived neurotrophic factor (BDNF) proteins were evaluated using 
      enzyme-linked immunosorbent assay. RESULTS: In the first experiment, duloxetine 
      at all doses attenuated methamphetamine withdrawal induced-depression, anxiety, 
      and motor disturbances in FST, OFT, EPM, and TST. In the second experiment, 
      duloxetine at all doses attenuated methamphetamine use-induced cognitive 
      impairment in MWM. In both experiments, duloxetine activated cAMP, CREB, and BDNF 
      proteins' expression in methamphetamine-treated rats. CONCLUSIONS: Duloxetine can 
      protect the brain against methamphetamine withdrawal-induced mood and motor 
      disturbances and can also inhibit methamphetamine-induced cognitive impairment, 
      possibly via cAMP/CREB/BDNF signaling pathway.
FAU - Ramezany Yasuj, Sanaz
AU  - Ramezany Yasuj S
AD  - Department of Pharmacology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Nourhashemi, Mona
AU  - Nourhashemi M
AD  - Department of Pharmacology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Keshavarzi, Saghar
AU  - Keshavarzi S
AD  - Department of Pharmacology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Motaghinejad, Majid
AU  - Motaghinejad M
AD  - Research Center for Addiction and Risky Behaviors (ReCARB), Iran Psychiatric 
      Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Motevalian, Manijeh
AU  - Motevalian M
AD  - Department of Pharmacology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190221
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC6425746
OTO - NOTNLM
OT  - Anxiety
OT  - cognition impairment
OT  - depression
OT  - duloxetine
OT  - methamphetamine
COIS- There are no conflicts of interest.
EDAT- 2019/04/18 06:00
MHDA- 2019/04/18 06:01
PMCR- 2019/02/21
CRDT- 2019/04/18 06:00
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2019/04/18 06:01 [medline]
PHST- 2019/02/21 00:00 [pmc-release]
AID - ABR-8-11 [pii]
AID - 10.4103/abr.abr_34_18 [doi]
PST - epublish
SO  - Adv Biomed Res. 2019 Feb 21;8:11. doi: 10.4103/abr.abr_34_18. eCollection 2019.