PMID- 30993153
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2352-1872 (Print)
IS  - 2352-1872 (Electronic)
IS  - 2352-1872 (Linking)
VI  - 10
DP  - 2019 Jun
TI  - Higher dose but not low dose proton pump inhibitors are associated with increased 
      risk of subsequent hip fractures after first hip fracture: A nationwide 
      observational cohort study.
PG  - 100204
LID - 10.1016/j.bonr.2019.100204 [doi]
LID - 100204
AB  - AIM: To examine the association of proton pump inhibitor (PPI) use with 
      subsequent hip fracture incidence in hip fracture patients, accounting for 
      gender, age, PPI doses, PPI initiation before or after first fracture, and year 
      from first fracture in which the first subsequent fracture occurred. METHODS: 
      Data from 31,668 Austrian patients >/=50 years with the first hip fracture between 
      July 2008 and December 2010 were analyzed retrospectively. After exclusion of 
      patients on anti-osteoporotic medication, incidence of subsequent hip fractures 
      was compared between users and non-users of PPIs using regression models. 
      RESULTS: In general, use of PPIs among hip fracture patients was associated with 
      increased risk for subsequent hip fracture (OR 1.58, 95%-CI 1.25-2.00), in 
      particular in men, in the age group of 70-84 years, and when PPIs were initiated 
      before the first fracture. Low PPI doses of </=90 cumulative DDDs and </=0.25 
      DDDs/day, however, were not linked to elevated subsequent fracture risk, 
      especially among female patients. Subsequent hip fracture incidence was elevated 
      within the first year after first fracture in female and male PPI users (OR 1.75, 
      95%-CI 1.28-2.38) and dropped in women but not in men in the second year. 
      CONCLUSIONS: Low-dose PPI use is not associated with increased risk of subsequent 
      hip fractures, especially in women. Patients thus get most benefit of short-term 
      PPI use after a hip fracture that has previously been linked to lowered mortality 
      if low doses are not exceeded. Varying risk profiles for the time of subsequent 
      hip fracture could have implications for risk group-specific follow-up care.
FAU - Brozek, Wolfgang
AU  - Brozek W
AD  - Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of the WGKK and AUVA 
      Trauma Center, 1 Medical Department at Hanusch Hospital, Heinrich Collin Str. 30, 
      1140 Vienna, Austria.
FAU - Reichardt, Berthold
AU  - Reichardt B
AD  - Sickness Fund Burgenland, Burgenlandische Gebietskrankenkasse, Siegfried Marcus 
      Str. 5, 7000 Eisenstadt, Austria.
FAU - Zwerina, Jochen
AU  - Zwerina J
AD  - Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of the WGKK and AUVA 
      Trauma Center, 1 Medical Department at Hanusch Hospital, Heinrich Collin Str. 30, 
      1140 Vienna, Austria.
FAU - Dimai, Hans Peter
AU  - Dimai HP
AD  - Department of Internal Medicine, Division of Endocrinology and Diabetology, 
      Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
FAU - Klaushofer, Klaus
AU  - Klaushofer K
AD  - Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of the WGKK and AUVA 
      Trauma Center, 1 Medical Department at Hanusch Hospital, Heinrich Collin Str. 30, 
      1140 Vienna, Austria.
FAU - Zwettler, Elisabeth
AU  - Zwettler E
AD  - Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of the WGKK and AUVA 
      Trauma Center, 1 Medical Department at Hanusch Hospital, Heinrich Collin Str. 30, 
      1140 Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20190401
PL  - United States
TA  - Bone Rep
JT  - Bone reports
JID - 101646176
PMC - PMC6451165
OTO - NOTNLM
OT  - Dosage
OT  - Hip fracture
OT  - Osteoporosis
OT  - Proton pump inhibitors
OT  - Subsequent fracture
EDAT- 2019/04/18 06:00
MHDA- 2019/04/18 06:01
PMCR- 2019/04/01
CRDT- 2019/04/18 06:00
PHST- 2018/06/18 00:00 [received]
PHST- 2019/02/26 00:00 [revised]
PHST- 2019/03/30 00:00 [accepted]
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2019/04/18 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - S2352-1872(19)30010-5 [pii]
AID - 100204 [pii]
AID - 10.1016/j.bonr.2019.100204 [doi]
PST - epublish
SO  - Bone Rep. 2019 Apr 1;10:100204. doi: 10.1016/j.bonr.2019.100204. eCollection 2019 
      Jun.