PMID- 30993592
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20240204
IS  - 1878-7479 (Electronic)
IS  - 1933-7213 (Print)
IS  - 1878-7479 (Linking)
VI  - 16
IP  - 4
DP  - 2019 Oct
TI  - Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus 
      of Parkinson's Disease Model Mice.
PG  - 1210-1224
LID - 10.1007/s13311-019-00732-5 [doi]
AB  - In this study, we have, for the first time, demonstrated the beneficial effects 
      of transcranial magneto-acoustic stimulation (TMAS), a technique based on focused 
      ultrasound stimulation within static magnetic field, on the learning and memory 
      abilities and neuroplasticity of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 
      (MPTP) mouse model of Parkinson's disease (PD). Our results showed that chronic 
      TMAS treatment (2 weeks) improved the outcome of Morris water maze, long-term 
      potentiation (LTP), and dendritic spine densities in the dentate gyrus (DG) 
      region of the hippocampus of PD model mice. To further investigate into the 
      underlying mechanisms of these beneficial effects by TMAS, we quantified the 
      proteins in the hippocampus that regulated neuroplasticity. Results showed that 
      the level of postsynaptic density protein 95 was elevated in the brain of 
      TMAS-treated PD model mice while the level of synaptophysin (SYP) did not show 
      any change. We further quantified proteins that mediated neuroplasticity 
      mechanisms, such as brain-derived neurotrophic factor (BDNF) and other important 
      proteins that mediated neuroplasticity. Results showed that TMAS treatment 
      elevated the levels of BDNF, cAMP response element-binding protein (CREB), and 
      protein kinase B (p-Akt) in the PD model mouse hippocampus, but not in the non-PD 
      mouse hippocampus. These results suggest that the beneficial effects on the 
      neuroplasticity of PD model mice treated with TMAS could possibly be conducted 
      through postsynaptic regulations and mediated by BDNF.
FAU - Wang, Yuexiang
AU  - Wang Y
AD  - College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Tianjin 
      Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai 
      University, Tianjin, 300071, China.
FAU - Feng, Lina
AU  - Feng L
AD  - College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Tianjin 
      Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai 
      University, Tianjin, 300071, China.
FAU - Liu, Shikun
AU  - Liu S
AD  - Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, Tianjin, 300192, China.
FAU - Zhou, Xiaoqing
AU  - Zhou X
AD  - Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, Tianjin, 300192, China.
FAU - Yin, Tao
AU  - Yin T
AD  - Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, Tianjin, 300192, China.
FAU - Liu, Zhipeng
AU  - Liu Z
AD  - Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, Tianjin, 300192, China. lzpeng67@163.com.
FAU - Yang, Zhuo
AU  - Yang Z
AUID- ORCID: 0000-0001-5212-0053
AD  - College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Tianjin 
      Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai 
      University, Tianjin, 300071, China. zhuoyang@nankai.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotherapeutics
JT  - Neurotherapeutics : the journal of the American Society for Experimental 
      NeuroTherapeutics
JID - 101290381
SB  - IM
EIN - Neurotherapeutics. 2019 Jul 9;:. PMID: 31290089
MH  - Acoustic Stimulation/*methods
MH  - Animals
MH  - Hippocampus/pathology/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/*physiology
MH  - Parkinsonian Disorders/pathology/*physiopathology/*therapy
MH  - Transcranial Magnetic Stimulation/*methods
PMC - PMC6985386
OTO - NOTNLM
OT  - Transcranial magneto-acoustic stimulation (TMAS)
OT  - brain-derived neurotrophic factor (BDNF)
OT  - dendritic spine
OT  - hippocampus
OT  - long-term potentiation (LTP)
EDAT- 2019/04/18 06:00
MHDA- 2020/08/25 06:00
PMCR- 2020/10/01
CRDT- 2019/04/18 06:00
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2019/04/18 06:00 [entrez]
PHST- 2020/10/01 00:00 [pmc-release]
AID - S1878-7479(23)00977-7 [pii]
AID - 732 [pii]
AID - 10.1007/s13311-019-00732-5 [doi]
PST - ppublish
SO  - Neurotherapeutics. 2019 Oct;16(4):1210-1224. doi: 10.1007/s13311-019-00732-5.