PMID- 30994805
OWN - NLM
STAT- MEDLINE
DCOM- 20190530
LR  - 20220409
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 52
DP  - 2019 Apr 11
TI  - Adverse events in patients with leprosy on treatment with thalidomide.
PG  - e20180385
LID - S0037-86822019000100639 [pii]
LID - 10.1590/0037-8682-0385-2018 [doi]
AB  - INTRODUCTION: Thalidomide, used to treat erythema nodosum leprosum (ENL), is 
      associated with severe adverse events (AEs) and is highly teratogenic. METHODS: A 
      cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs 
      and selected variables were investigated through interviews and assessment of 
      medical records. Odds ratios with 95% confidence intervals were estimated via 
      logistic regression. RESULTS: Peripheral neuropathy symptoms and deep vein 
      thrombosis (DVT) were the most common AEs reported. Although women of 
      reproductive age used contraceptives, <50% of patients reported using condoms. 
      Polypharmacy was associated with all endpoints, except DVT. CONCLUSIONS: 
      Pharmacovigilance is crucial to prevent harmful thalidomide-associated AEs.
FAU - Drummond, Paula Lana de Miranda
AU  - Drummond PLM
AUID- ORCID: 0000-0002-4639-7424
AD  - Divisao de Assuntos Regulatorios, Diretoria Industrial, Fundacao Ezequiel Dias, 
      Belo Horizonte, MG, Brasil.
AD  - Departamento de Farmacia Social, Faculdade de Farmacia, Universidade Federal de 
      Minas Gerais, Belo Horizonte, MG, Brasil.
FAU - Santos, Roberta Marcia Marques Dos
AU  - Santos RMMD
AD  - Divisao de Assuntos Regulatorios, Diretoria Industrial, Fundacao Ezequiel Dias, 
      Belo Horizonte, MG, Brasil.
FAU - Carvalho, Gabriela Oliveira
AU  - Carvalho GO
AD  - Departamento de Farmacia Social, Faculdade de Farmacia, Universidade Federal de 
      Minas Gerais, Belo Horizonte, MG, Brasil.
FAU - Padua, Cristiane Aparecida Menezes de
AU  - Padua CAM
AD  - Departamento de Farmacia Social, Faculdade de Farmacia, Universidade Federal de 
      Minas Gerais, Belo Horizonte, MG, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20190411
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
RN  - 0 (Leprostatic Agents)
RN  - 4Z8R6ORS6L (Thalidomide)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Leprostatic Agents/*adverse effects/therapeutic use
MH  - Leprosy/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Thalidomide/*adverse effects/therapeutic use
EDAT- 2019/04/18 06:00
MHDA- 2019/05/31 06:00
CRDT- 2019/04/18 06:00
PHST- 2018/09/13 00:00 [received]
PHST- 2018/12/17 00:00 [accepted]
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2019/05/31 06:00 [medline]
AID - S0037-86822019000100639 [pii]
AID - 10.1590/0037-8682-0385-2018 [doi]
PST - epublish
SO  - Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180385. doi: 
      10.1590/0037-8682-0385-2018.