PMID- 30995318
OWN - NLM
STAT- MEDLINE
DCOM- 20190920
LR  - 20190920
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 60
IP  - 5
DP  - 2019 Apr 1
TI  - Cone-Mediated Function Correlates to Altered Foveal Morphology in Preterm-Born 
      Children at School Age.
PG  - 1614-1620
LID - 10.1167/iovs.18-24892 [doi]
AB  - PURPOSE: To correlate cone- and rod-mediated function with morphology of the 
      macula in preterm-born children without and with spontaneously regressed 
      retinopathy of prematurity (ROP). METHODS: We performed spectral-domain optical 
      coherence tomography (SD-OCT) single scans in the macular center of preterm-born 
      children aged 6 to 12 years (mean +/- SD, 7.4 +/- 1.8) without ROP (noROP; n = 59) 
      and with spontaneously regressed ROP (srROP; n = 34), documented with wide-angle 
      digital imaging during routine screening for acute ROP, and compared the data 
      from 14 age-matched term-born children. SD-OCT data were compared to functional 
      cone- and rod-mediated results of scotopic and photopic chromatic pupillometry 
      (cP) and two-color fundus-controlled perimetry (2C-FCP). RESULTS: SD-OCT showed a 
      shallowed foveal pit with significantly reduced outer nuclear layer to inner 
      retinal layer ratio, indicating macular developmental arrest (MDA). MDA was 
      present in 44% of the srROP and 27% of the noROP children. Pupil reaction to 
      photopic red stimuli on blue background showed significantly lower values in all 
      preterm-born children with MDA. In accordance, photopic light increment 
      sensitivity (LIS) to red stimuli in the foveal center on the 2C-FCP was also 
      significantly reduced in children with MDA. Under scotopic conditions, no 
      significant differences were apparent in both pupil reaction with cP and LIS with 
      2C-FCP. CONCLUSIONS: Both objective pupillary response to cone-mediated photopic 
      red stimuli and subjective central cone-mediated results in fundus-controlled 
      perimetry were reduced in preterm-born children with MDA. MDA was present in a 
      significant number of patients with srROP, but also without ROP.
FAU - Bowl, Wadim
AU  - Bowl W
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Raoof, Sinan
AU  - Raoof S
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Lorenz, Birgit
AU  - Lorenz B
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Holve, Kerstin
AU  - Holve K
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Schweinfurth, Silke
AU  - Schweinfurth S
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Stieger, Knut
AU  - Stieger K
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Andrassi-Darida, Monika
AU  - Andrassi-Darida M
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Birth Weight
MH  - Child
MH  - Color Vision/physiology
MH  - Female
MH  - Fovea Centralis/diagnostic imaging/*pathology
MH  - Gestational Age
MH  - Humans
MH  - Male
MH  - Night Vision/physiology
MH  - *Premature Birth
MH  - Pupil/physiology
MH  - Retinal Cone Photoreceptor Cells/*physiology
MH  - Retinopathy of Prematurity/diagnostic imaging/*physiopathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity
MH  - Visual Field Tests
EDAT- 2019/04/18 06:00
MHDA- 2019/09/21 06:00
CRDT- 2019/04/18 06:00
PHST- 2019/04/18 06:00 [entrez]
PHST- 2019/04/18 06:00 [pubmed]
PHST- 2019/09/21 06:00 [medline]
AID - 2731698 [pii]
AID - 10.1167/iovs.18-24892 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1614-1620. doi: 
      10.1167/iovs.18-24892.