PMID- 30995790
OWN - NLM
STAT- MEDLINE
DCOM- 20190905
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 4
DP  - 2019 Apr 16
TI  - The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in 
      Depressive Mice.
LID - 10.3390/nu11040859 [doi]
LID - 859
AB  - Major depressive disorder (MDD) is a chronic mental disorder characterized by 
      mixed symptoms and complex pathogenesis. With long history of practical 
      application, traditional Chinese medicine (TCM) offers many herbs for the 
      treatment and rehabilitation of chronic disease. In this study, we developed a 
      modified Chinese herbal formula using Panax ginseng, Angelica Sinensis, Polygala 
      tenuifolia Willd, and Ziziphi spinosae Semen (PAPZ), based on an ancient TCM 
      prescription. The antidepressant effects of PAPZ were investigated with a 
      corticosterone (CORT) model of depression in mice. Our results showed that 
      administration of PAPZ ameliorated depression-like phenotypes in the CORT model. 
      An anatomic study showed that chronic PAPZ administration upregulated the protein 
      expression of brain-derived neurotrophic factor (BDNF) in hippocampal tissue. The 
      enzyme activity of superoxide dismutase was enhanced in hippocampal tissue, in 
      line with a decreased malondialdehyde level. Taken together, these findings 
      suggested that PAPZ has therapeutic effects in a mice depression model through 
      increasing protein expression of BDNF and improving the anti-oxidation ability of 
      the brain.
FAU - Chen, Huiling
AU  - Chen H
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. chenhl16@mails.tsinghua.edu.cn.
FAU - Huang, Qing
AU  - Huang Q
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. qinghuangfgh@163.com.
AD  - School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 
      2668501, Japan. qinghuangfgh@163.com.
FAU - Zhang, Shunjia
AU  - Zhang S
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. shunjia.zhang@yale.edu.
AD  - Environmental Health Science, School of Public Health, Yale University, New 
      Haven, CT 06520, USA. shunjia.zhang@yale.edu.
FAU - Hu, Kaiqiang
AU  - Hu K
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. hkq15@mails.tsinghua.edu.cn.
FAU - Xiong, Wenxiang
AU  - Xiong W
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. xiongwxiang@163.com.
FAU - Xiao, Lingyun
AU  - Xiao L
AD  - Research & Development Centre, Infinitus (China) Company Ltd., Guangzhou 510663, 
      China. xiaolingyun12@126.com.
FAU - Cong, Renhuai
AU  - Cong R
AD  - Research & Development Centre, Infinitus (China) Company Ltd., Guangzhou 510663, 
      China. Renhuai.Cong@infinitus-int.com.
FAU - Liu, Qingfei
AU  - Liu Q
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. liuqf@tsinghua.edu.cn.
FAU - Wang, Zhao
AU  - Wang Z
AD  - MOE Key Laboratory of Protein Science, School of Pharmaceutical Sciences, 
      Tsinghua University, Beijing 100084, China. zwang@tsinghua.edu.cn.
LA  - eng
GR  - 2018YFD0400204/The National Key R&D Program of China/
GR  - 2016YFE113700/The Key International S&T Cooperation Program of China/
GR  - 633589/The European Union's Horizon 2020 Research and Innovation Program/
GR  - 81471396, 81871095/The National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20190416
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Angelica sinensis
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Antioxidants/metabolism/pharmacology/*therapeutic use
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone
MH  - Depression/*drug therapy/metabolism
MH  - Depressive Disorder, Major/drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Hippocampus/*drug effects/metabolism
MH  - *Magnoliopsida
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Mice, Inbred C57BL
MH  - Panax
MH  - *Phytotherapy
MH  - Polygala
MH  - Superoxide Dismutase/metabolism
MH  - Ziziphus
PMC - PMC6521158
OTO - NOTNLM
OT  - BDNF
OT  - Chinese herbal formula
OT  - corticosterone
OT  - major depressive disorder
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2019/04/19 06:00
MHDA- 2019/09/07 06:00
PMCR- 2019/04/01
CRDT- 2019/04/19 06:00
PHST- 2019/03/11 00:00 [received]
PHST- 2019/04/07 00:00 [revised]
PHST- 2019/04/12 00:00 [accepted]
PHST- 2019/04/19 06:00 [entrez]
PHST- 2019/04/19 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - nu11040859 [pii]
AID - nutrients-11-00859 [pii]
AID - 10.3390/nu11040859 [doi]
PST - epublish
SO  - Nutrients. 2019 Apr 16;11(4):859. doi: 10.3390/nu11040859.