PMID- 30997127
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210203
LR  - 20210203
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 6
IP  - 1
DP  - 2019
TI  - Factors associated with health-related quality of life among adults with 
      tetralogy of Fallot.
PG  - e000932
LID - 10.1136/openhrt-2018-000932 [doi]
LID - e000932
AB  - BACKGROUND: Due to improved care, the numbers of patients with tetralogy of 
      Fallot (ToF) are increasing. However, long-term morbidity and need for 
      reinterventions are concerns and also address issues of quality of life (QoL). 
      METHODS: Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) 
      were identified in the national Swedish register on congenital heart disease. 
      EQ-5D(index) was calculated and dichotomised into best possible health-related 
      QoL (EQ-5D(index)=1) or differed from 1. RESULTS: 288 patients met the criteria 
      and were analysed. Univariate logistic regression showed a positive association 
      between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 
      18.21), physical activity >3 h/week (OR 3.34, 95% CI 1.67 to 6.66) and a better 
      right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association 
      between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 
      0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5D(index) 
      was observed. In multivariate logistic regression, NYHA I (OR 7.28, 95% CI 3.29 
      to 16.12) and physical activity >3 h/week (OR 2.27, 95% CI 1.07 to 4.84) remained 
      associated with best possible health-related QoL. Replacing NYHA with symptoms in 
      the model yielded similar results. CONCLUSION: In this registry study, 
      self-reported physical activity, staff-reported NYHA class and absence of 
      symptoms were strongly associated with best possible health-related QoL measured 
      by EQ-5D. Physical activity level is a potential target for intervention to 
      improve QoL in this population but randomised trials are needed to test such a 
      hypothesis.
FAU - Sandtrom, Anette
AU  - Sandtrom A
AD  - Heart Centre and Department of Public Health and Clinical Medicine, Umea 
      University, Umea, Sweden.
FAU - Sandberg, Camilla
AU  - Sandberg C
AD  - Heart Centre and Department of Public Health and Clinical Medicine, Umea 
      University, Umea, Sweden.
FAU - Rinnstrom, Daniel
AU  - Rinnstrom D
AD  - Heart Centre and Department of Public Health and Clinical Medicine, Umea 
      University, Umea, Sweden.
FAU - Engstrom, Gunnar
AU  - Engstrom G
AD  - Heart Centre and Department of Public Health and Clinical Medicine, Umea 
      University, Umea, Sweden.
FAU - Dellborg, Mikael
AU  - Dellborg M
AD  - Department of Molecular and Clinical Medicine, University of Gothenburg, 
      Gothenburg, Sweden.
FAU - Thilen, Ulf
AU  - Thilen U
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
FAU - Sorensson, Peder
AU  - Sorensson P
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Nielsen, Niels-Erik
AU  - Nielsen NE
AD  - Department of Medical and Health Sciences, Linkoping University, Linkoping, 
      Sweden.
FAU - Christersson, Christina
AU  - Christersson C
AD  - Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
FAU - Johansson, Bengt
AU  - Johansson B
AUID- ORCID: 0000-0003-0976-6910
AD  - Heart Centre and Department of Public Health and Clinical Medicine, Umea 
      University, Umea, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190227
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC6443137
OTO - NOTNLM
OT  - congenital heart disease
OT  - physical activity
OT  - quality of life
OT  - register
OT  - tetralogy of fallot
COIS- Competing interests: None declared.
EDAT- 2019/04/19 06:00
MHDA- 2019/04/19 06:01
PMCR- 2019/02/27
CRDT- 2019/04/19 06:00
PHST- 2018/09/06 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/12/20 00:00 [accepted]
PHST- 2019/04/19 06:00 [entrez]
PHST- 2019/04/19 06:00 [pubmed]
PHST- 2019/04/19 06:01 [medline]
PHST- 2019/02/27 00:00 [pmc-release]
AID - openhrt-2018-000932 [pii]
AID - 10.1136/openhrt-2018-000932 [doi]
PST - epublish
SO  - Open Heart. 2019 Feb 27;6(1):e000932. doi: 10.1136/openhrt-2018-000932. 
      eCollection 2019.