PMID- 30998186
OWN - NLM
STAT- MEDLINE
DCOM- 20200228
LR  - 20210318
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 8
DP  - 2019 Apr 18
TI  - Oligodendrocytes regulate presynaptic properties and neurotransmission through 
      BDNF signaling in the mouse brainstem.
LID - 10.7554/eLife.42156 [doi]
LID - e42156
AB  - Neuron-glia communication contributes to the fine-tuning of synaptic functions. 
      Oligodendrocytes near synapses detect and respond to neuronal activity, but their 
      role in synapse development and plasticity remains largely unexplored. We show 
      that oligodendrocytes modulate neurotransmitter release at presynaptic terminals 
      through secretion of brain-derived neurotrophic factor (BDNF). 
      Oligodendrocyte-derived BDNF functions via presynaptic tropomyosin receptor 
      kinase B (TrkB) to ensure fast, reliable neurotransmitter release and auditory 
      transmission in the developing brain. In auditory brainstem slices from Bdnf(+/-) 
      mice, reduction in endogenous BDNF significantly decreased vesicular glutamate 
      release by reducing the readily releasable pool of glutamate vesicles, without 
      altering presynaptic Ca(2+) channel activation or release probability. Using 
      conditional knockout mice, cell-specific ablation of BDNF in oligodendrocytes 
      largely recapitulated this effect, which was recovered by BDNF or TrkB agonist 
      application. This study highlights a novel function for oligodendrocytes in 
      synaptic transmission and their potential role in the activity-dependent 
      refinement of presynaptic properties.
CI  - (c) 2019, Jang et al.
FAU - Jang, Miae
AU  - Jang M
AD  - The Department of Cellular and Integrative Physiology, University of Texas Health 
      Science Center, San Antonio, United States.
FAU - Gould, Elizabeth
AU  - Gould E
AD  - The Department of Cellular and Integrative Physiology, University of Texas Health 
      Science Center, San Antonio, United States.
FAU - Xu, Jie
AU  - Xu J
AD  - The Department of Cellular and Integrative Physiology, University of Texas Health 
      Science Center, San Antonio, United States.
AD  - Children's Medical Center, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Kim, Eun Jung
AU  - Kim EJ
AD  - The Department of Cellular and Integrative Physiology, University of Texas Health 
      Science Center, San Antonio, United States.
FAU - Kim, Jun Hee
AU  - Kim JH
AUID- ORCID: 0000-0003-0207-8410
AD  - The Department of Cellular and Integrative Physiology, University of Texas Health 
      Science Center, San Antonio, United States.
LA  - eng
GR  - T32 HL007446/HL/NHLBI NIH HHS/United States
GR  - R01 DC03157/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190418
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Brain Stem/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Gene Knockout Techniques
MH  - Membrane Glycoproteins/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Oligodendroglia/*physiology
MH  - Presynaptic Terminals/*physiology
MH  - Protein-Tyrosine Kinases/metabolism
MH  - *Synaptic Transmission
PMC - PMC6504230
OTO - NOTNLM
OT  - BDNF
OT  - auditory brainstem
OT  - mouse
OT  - neuroscience
OT  - oligodendrocytes
OT  - presynaptic terminal
COIS- MJ, EG, JX, EK, JK No competing interests declared
EDAT- 2019/04/19 06:00
MHDA- 2020/02/29 06:00
PMCR- 2019/04/18
CRDT- 2019/04/19 06:00
PHST- 2018/09/21 00:00 [received]
PHST- 2019/04/17 00:00 [accepted]
PHST- 2019/04/19 06:00 [pubmed]
PHST- 2020/02/29 06:00 [medline]
PHST- 2019/04/19 06:00 [entrez]
PHST- 2019/04/18 00:00 [pmc-release]
AID - 42156 [pii]
AID - 10.7554/eLife.42156 [doi]
PST - epublish
SO  - Elife. 2019 Apr 18;8:e42156. doi: 10.7554/eLife.42156.