PMID- 30998240
OWN - NLM
STAT- MEDLINE
DCOM- 20191217
LR  - 20230919
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Print)
IS  - 2325-8160 (Linking)
VI  - 50
IP  - 4
DP  - 2019 Apr 1
TI  - Early Diagnosis and Management of Aggressive Posterior Vitreoretinopathy 
      Presenting in Premature Neonates.
PG  - 201-207
LID - 10.3928/23258160-20190401-01 [doi]
AB  - BACKGROUND AND OBJECTIVE: Aggressive posterior vitreoretinopathy (APVR) manifests 
      with a broad area of retinal avascularity, progressive neovascularization, and/or 
      tractional retinal detachment during the neonatal period. PATIENTS AND METHODS: A 
      multicenter, retrospective, observational, consecutive case series study was 
      performed to evaluate the retinal findings and structural retinal outcomes in 
      patients treated for APVR within the first 3 months of life. RESULTS: Three 
      premature neonates with a non-retinopathy of prematurity (ROP) APVR identified 
      during routine ROP screening exams exhibited relatively severe, rapidly 
      progressive retinal vascular abnormalities. Immediate laser photocoagulation of 
      the avascular retina and vitrectomy for traction retinal detachment within 
      several days to weeks improved or stabilized the retinal anatomy in all cases. 
      CONCLUSIONS: This series describes clinical features in APVR in premature infants 
      and suggests that early diagnosis and intervention may mitigate the typical 
      aggressive course and poor prognosis of this condition. [Ophthalmic Surg Lasers 
      Imaging Retina. 2019;50:201-207.].
CI  - Copyright 2019, SLACK Incorporated.
FAU - Gupta, Mrinali P
AU  - Gupta MP
FAU - Yonekawa, Yoshihiro
AU  - Yonekawa Y
FAU - Campbell, J Peter
AU  - Campbell JP
FAU - Rusu, Irene
AU  - Rusu I
FAU - Zahid, Sarwar
AU  - Zahid S
FAU - Patel, Samir N
AU  - Patel SN
FAU - Chau, Felix
AU  - Chau F
FAU - Jonas, Karyn E
AU  - Jonas KE
FAU - Oltra, Erica
AU  - Oltra E
FAU - Orlin, Anton
AU  - Orlin A
FAU - Chang, Jonathan
AU  - Chang J
FAU - Horowitz, Jason
AU  - Horowitz J
FAU - Abramson, David H
AU  - Abramson DH
FAU - Marr, Brian
AU  - Marr B
FAU - Capone, Antonio
AU  - Capone A
FAU - Paul Chan, R V
AU  - Paul Chan RV
LA  - eng
GR  - R01 EY019474/EY/NEI NIH HHS/United States
GR  - P30 EY001792/EY/NEI NIH HHS/United States
GR  - P30 EY010572/EY/NEI NIH HHS/United States
GR  - P30 EY001765/EY/NEI NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - K12 EY027720/EY/NEI NIH HHS/United States
GR  - R01 HD107493/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Disease Management
MH  - *Early Diagnosis
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Fundus Oculi
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intravitreal Injections
MH  - Laser Therapy/*methods
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
MH  - Visual Acuity
MH  - Vitrectomy/*methods
MH  - Vitreoretinopathy, Proliferative/*diagnosis/drug therapy/surgery
PMC - PMC7864674
MID - NIHMS1666083
EDAT- 2019/04/19 06:00
MHDA- 2019/12/18 06:00
PMCR- 2021/02/05
CRDT- 2019/04/19 06:00
PHST- 2018/06/26 00:00 [received]
PHST- 2019/01/03 00:00 [accepted]
PHST- 2019/04/19 06:00 [entrez]
PHST- 2019/04/19 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2021/02/05 00:00 [pmc-release]
AID - 10.3928/23258160-20190401-01 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2019 Apr 1;50(4):201-207. doi: 
      10.3928/23258160-20190401-01.