PMID- 30999065
OWN - NLM
STAT- MEDLINE
DCOM- 20191217
LR  - 20191217
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 102
DP  - 2019 Jun
TI  - Periodontal condition of patients with Thalassemia Major: A systematic review and 
      meta-analysis.
PG  - 113-121
LID - S0003-9969(18)30905-1 [pii]
LID - 10.1016/j.archoralbio.2019.04.004 [doi]
AB  - OBJECTIVES: The aim of this systematic review was to evaluate the existing 
      evidence on the association between Thalassemia major (TM) and periodontal 
      condition. MATERIALS & METHODS: MEDLINE via OVID, EMBASE, and The Cochrane 
      Database (including the Central Register of Controlled Trials (CENTER)), were 
      searched up to September 2018 to identify observational studies eligible for 
      systematic review and meta-analyses. Newcastle-Ottawa Scale (NOS) was used for 
      quality assessment. RESULTS: The initial search resulted in 172 articles, and of 
      these, 16 articles were included and a qualitative synthesis was carried out. 
      Based on the quantitative data from 14 studies, significant differences were 
      found in gingival index (GI) (p < 0.001), bleeding on probing (p = 0.02) as well 
      as plaque index (PI) (p < 0.01) measures between TM and systemically healthy 
      controls. Additional analyses (young vs. adult) for GI and PI revealed that such 
      significant differences were only observed in adults, even though overall 
      analysis showed no subgroup effect. The majority of the studies qualified as 
      "intermediate quality". CONCLUSION: Patients with TM had significantly higher 
      gingival inflammation scores compared to controls. Therefore, routine 
      comprehensive periodontal screening in TM is recommended in order to prevent 
      occurrence of periodontal diseases and eventually reduce the complexity of the 
      oral health care. Also, conduction of further well-designed observational studies 
      is recommended to contribute to this topic.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Akcali, Aliye
AU  - Akcali A
AD  - Department of Periodontology, School of Dentistry, Faculty of Health, 
      Witten/Herdecke University, Witten, Germany; Centre for Oral Clinical Research, 
      Institute of Dentistry, Barts &The London School of Medicine and Dentistry, Queen 
      Mary University of London (QMUL), London, United Kingdom. Electronic address: 
      aliyeakcali@hotmail.com.
FAU - Yildiz, Mehmet Selim
AU  - Yildiz MS
AD  - Department of Periodontology, School of Dentistry, Faculty of Health, 
      Witten/Herdecke University, Witten, Germany.
FAU - Akcali, Zeynep
AU  - Akcali Z
AD  - Department of Internal Medicine, Havran Government Hospital, Balikesir, Turkey.
FAU - Huck, Olivier
AU  - Huck O
AD  - Universite de Strasbourg, Faculte de Chirurgie Dentaire, Periodontology, 
      Strasbourg, France; INSERM 1260 << Regenerative Nanomedicine >>, Federation de 
      Medecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
FAU - Friedmann, Anton
AU  - Friedmann A
AD  - Department of Periodontology, School of Dentistry, Faculty of Health, 
      Witten/Herdecke University, Witten, Germany.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190409
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
SB  - IM
CIN - J Evid Based Dent Pract. 2020 Jun;20(2):101412. PMID: 32473800
MH  - Adult
MH  - Dental Plaque Index
MH  - *Gingivitis
MH  - Humans
MH  - *Periodontal Diseases
MH  - Periodontal Index
MH  - *beta-Thalassemia
OTO - NOTNLM
OT  - Gingivitis
OT  - Oral health
OT  - Periodontal diseases
OT  - Periodontal indexes
OT  - Periodontitis
OT  - Thalassemia major
EDAT- 2019/04/19 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/04/19 06:00
PHST- 2018/12/14 00:00 [received]
PHST- 2019/04/04 00:00 [revised]
PHST- 2019/04/08 00:00 [accepted]
PHST- 2019/04/19 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/04/19 06:00 [entrez]
AID - S0003-9969(18)30905-1 [pii]
AID - 10.1016/j.archoralbio.2019.04.004 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2019 Jun;102:113-121. doi: 10.1016/j.archoralbio.2019.04.004. 
      Epub 2019 Apr 9.