PMID- 30999946
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20200225
IS  - 1757-2215 (Electronic)
IS  - 1757-2215 (Linking)
VI  - 12
IP  - 1
DP  - 2019 Apr 18
TI  - A potential function of RLIP76 in the ovarian corpus luteum.
PG  - 34
LID - 10.1186/s13048-019-0510-8 [doi]
LID - 34
AB  - Ral interacting protein of 76 kDa (RLIP76) is multifunctional protein localized 
      and distributed in the plasma membrane, cytosol, and nucleus of the cell. In 
      tumorigenesis, RLIP76 emerges as a common feature for the solid tumor growth. 
      RLIP76 is ubiquitously expressed in various tissues including the ovary. 
      Interestingly, the similar physiological events in obtaining an adequate supply 
      of nutrient by gaining access to the host vascular system are required either for 
      corpus luteum formation or tumor development. In addition, the identical 
      angiogenesis modulators were found in neoplastic and normal ovaries. Our previous 
      study involving RLIP76-/- mice implanted with melanoma or carcinoma cell 
      conclusively demonstrated that RLIP76 is necessary for angiogenesis and 
      neovascularization of primary solid tumors. RLIP76 plays an essential role in 
      tumor angiogenesis through the regulation of pro-angiogenic factors such as 
      vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1). 
      In certain previous studies, those pro-angiogenic factors were found 
      significantly to be upregulated during the corpus luteum formation. To that, the 
      following review will discuss the likelihood of RLIP76 role in ovarian corpus 
      luteum.
FAU - Billhaq, Dody Houston
AU  - Billhaq DH
AD  - College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, 
      Republic of Korea.
FAU - Lee, Seunghyung
AU  - Lee S
AUID- ORCID: 0000-0001-5862-3663
AD  - College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, 
      Republic of Korea. s.lee@kangwon.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190418
PL  - England
TA  - J Ovarian Res
JT  - Journal of ovarian research
JID - 101474849
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (RALBP1 protein, human)
SB  - IM
MH  - ATP-Binding Cassette Transporters/*metabolism
MH  - Animals
MH  - Apoptosis/physiology
MH  - Corpus Luteum/blood supply/cytology/*metabolism
MH  - Female
MH  - GTPase-Activating Proteins/*metabolism
MH  - Humans
MH  - Ovarian Neoplasms/blood supply/metabolism
PMC - PMC6474048
OTO - NOTNLM
OT  - Angiogenesis
OT  - Corpus luteum
OT  - Ovary
OT  - RLIP76
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable. CONSENT FOR 
      PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they 
      have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2019/04/20 06:00
MHDA- 2019/09/04 06:00
PMCR- 2019/04/18
CRDT- 2019/04/20 06:00
PHST- 2019/02/01 00:00 [received]
PHST- 2019/04/08 00:00 [accepted]
PHST- 2019/04/20 06:00 [entrez]
PHST- 2019/04/20 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/04/18 00:00 [pmc-release]
AID - 10.1186/s13048-019-0510-8 [pii]
AID - 510 [pii]
AID - 10.1186/s13048-019-0510-8 [doi]
PST - epublish
SO  - J Ovarian Res. 2019 Apr 18;12(1):34. doi: 10.1186/s13048-019-0510-8.