PMID- 31000384 OWN - NLM STAT- MEDLINE DCOM- 20191206 LR - 20191217 IS - 1876-4754 (Electronic) IS - 1876-4754 (Linking) VI - 12 IP - 4 DP - 2019 Jul-Aug TI - Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression. PG - 1041-1050 LID - S1935-861X(19)30068-3 [pii] LID - 10.1016/j.brs.2019.02.015 [doi] AB - INTRODUCTION: The induction of brain-derived neurotrophic factor (BDNF) release and subsequent restoration of neuroplastic homeostasis may underlie the effects of electroconvulsive therapy (ECT). OBJECTIVES: We aimed to assess serum and plasma BDNF levels during the course of acute ECT, as well as before and after subsequent continuation ECT, in patients with depression. METHODS: We included 24 patients with major depressive disorder (mean age +/- SD: 54.5 +/- 13.7; f/m: 17/7; baseline 17-item Hamilton Depression Rating Scale score of 26.79 +/- 4.01). Serum and plasma BDNF (sBDNF, pBDNF) levels were assessed at nine time-points before, during, and after acute ECT series. Data were analysed using linear regression and linear mixed models, which were adjusted for multiple comparisons via Bonferroni correction. Five patients received continuation ECT subsequent to the acute ECT series. In these patients, BDNF levels were assessed before and after each two continuation ECT sessions using Wilcoxon signed-rank tests. RESULTS: Relative to baseline (mean ng/ml +/-SD: 24.68 +/- 14.40), sBDNF levels were significantly higher 1 day (33.04 +/- 14.11, p = 0.013, corrected), 1 week (37.03 +/- 10.29, p < 0.001, corrected), and 1 month (41.05 +/- 10.67, p = 0.008, corrected) after the final ECT session, while pBDNF levels did not significantly differ (p > 0.1). Furthermore, our results indicated that sBDNF levels increased after each continuation ECT session. There was no significant association between sBDNF levels and clinical parameters or treatment response. CONCLUSION: The absence of an association between changes in sBDNF levels and depressive symptoms challenges the proposed concept of sBDNF/pBDNF as key markers of the effects of ECT. CI - Copyright (c) 2019. Published by Elsevier Inc. FAU - Vanicek, Thomas AU - Vanicek T AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: thomas.vanicek@meduniwien.ac.at. FAU - Kranz, Georg S AU - Kranz GS AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, M1504, Li Ka Shing Tower, Hong Kong; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, 5 Sassoon R., Pokfulam, Hong Kong. Electronic address: georg.kranz@polyu.edu.hk. FAU - Vyssoki, Benjamin AU - Vyssoki B AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: benjamin.vyssoki@meduniwien.ac.at. FAU - Fugger, Gernot AU - Fugger G AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: gernot.fugger@meduniwien.ac.at. FAU - Komorowski, Arkadiusz AU - Komorowski A AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: arkadiusz.komorowski@meduniwien.ac.at. FAU - Hoflich, Anna AU - Hoflich A AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: anna.hoeflich@meduniwien.ac.at. FAU - Saumer, Gertraud AU - Saumer G AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: saumer@psy-wien.com. FAU - Milovic, Sergej AU - Milovic S AD - Department of Anesthesia, Critical Care and Pain Medicine, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: sergej.milovic@meduniwien.ac.at. FAU - Lanzenberger, Rupert AU - Lanzenberger R AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: rupert.lanzenberger@meduniwien.ac.at. FAU - Eckert, Anne AU - Eckert A AD - Neurobiology Lab for Brain Aging and Mental Health, Transfaculty Research Platform Molecular & Cognitive Neuroscience (MCN), University of Basel, Birmannsgasse 8, 4055, Basel, Switzerland. Electronic address: Anne.Eckert@upkbs.ch. FAU - Kasper, Siegfried AU - Kasper S AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: gen-psychiatry@meduniwien.ac.at. FAU - Frey, Richard AU - Frey R AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address: richard.frey@meduniwien.ac.at. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190226 PL - United States TA - Brain Stimul JT - Brain stimulation JID - 101465726 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Aged MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Depressive Disorder, Major/*blood/psychology/*therapy MH - Electroconvulsive Therapy/*methods/trends MH - Female MH - Humans MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Neuronal Plasticity/physiology MH - Treatment Outcome OTO - NOTNLM OT - BDNF OT - Brain-derived neurotrophic factor OT - ECT OT - Electroconvulsive therapy OT - Major depressive disorder EDAT- 2019/04/20 06:00 MHDA- 2019/12/18 06:00 CRDT- 2019/04/20 06:00 PHST- 2018/08/13 00:00 [received] PHST- 2019/02/15 00:00 [revised] PHST- 2019/02/18 00:00 [accepted] PHST- 2019/04/20 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/04/20 06:00 [entrez] AID - S1935-861X(19)30068-3 [pii] AID - 10.1016/j.brs.2019.02.015 [doi] PST - ppublish SO - Brain Stimul. 2019 Jul-Aug;12(4):1041-1050. doi: 10.1016/j.brs.2019.02.015. Epub 2019 Feb 26.