PMID- 31002004
OWN - NLM
STAT- MEDLINE
DCOM- 20200409
LR  - 20200409
IS  - 2326-3660 (Electronic)
IS  - 0091-3847 (Linking)
VI  - 47
IP  - 4
DP  - 2019 Nov
TI  - Does brain-derived neurotrophic factor mediate the effects of exercise on memory?
PG  - 395-405
LID - 10.1080/00913847.2019.1610255 [doi]
AB  - Objective: Brain-derived neurotrophic factor (BDNF) has been hypothesized as a 
      potential mechanism through which exercise may subserve memory function. The 
      present review specifically evaluates this hypothesis.Methods: Studies were 
      identified using electronic databases, including PubMed, PsychInfo, Sports Discus 
      and Google Scholar.Results: In total, 52 articles met the study criteria, and 
      among these, 36 were conducted in an animal model and 16 among humans. Among the 
      animal experiments, 100% of them demonstrated that chronic exercise improved 
      memory function; 97% demonstrated an exercise-induced increase in BDNF; and among 
      the eight evaluating BDNF as a mediator, 100% provided evidence that BDNF 
      mediated the relationship between exercise and memory. The findings in the human 
      studies were mixed. Among the human studies, 44% demonstrated that varying 
      exercise protocols improved memory and increased BDNF levels, and among the 
      studies evaluating BDNF as a mediator, 40% provided evidence that BDNF mediated 
      the relationship between exercise and memory.Conclusion: In animal models, 
      chronic exercise training robustly increases BDNF and improves memory 
      performance, with reasonable evidence to also suggest that BDNF may mediate the 
      exercise-memory interaction. These interrelationships, however, are less clear 
      among humans. Future research among humans, in particular, is needed to evaluate 
      the extent to which BDNF may mediate the relationship between exercise and 
      memory.
FAU - Loprinzi, Paul D
AU  - Loprinzi PD
AD  - Exercise & Memory Laboratory, Department of Health, Exercise Science and 
      Recreation Management, University of Mississippi, University, MS, USA.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20190427
PL  - England
TA  - Phys Sportsmed
JT  - The Physician and sportsmedicine
JID - 0427461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Cognition
MH  - *Exercise
MH  - Humans
MH  - Male
MH  - *Memory
OTO - NOTNLM
OT  - Cognition
OT  - neurotrophin
OT  - physical activity
OT  - synaptic plasticity
EDAT- 2019/04/20 06:00
MHDA- 2020/04/10 06:00
CRDT- 2019/04/20 06:00
PHST- 2019/04/20 06:00 [pubmed]
PHST- 2020/04/10 06:00 [medline]
PHST- 2019/04/20 06:00 [entrez]
AID - 10.1080/00913847.2019.1610255 [doi]
PST - ppublish
SO  - Phys Sportsmed. 2019 Nov;47(4):395-405. doi: 10.1080/00913847.2019.1610255. Epub 
      2019 Apr 27.