PMID- 31002178
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20200804
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 33
IP  - 6
DP  - 2019 Jun
TI  - Nutrition-related factors associated with waiting list mortality in patients with 
      interstitial lung disease: A retrospective cohort study.
PG  - e13566
LID - 10.1111/ctr.13566 [doi]
AB  - Japanese patients with interstitial lung disease (ILD) sometimes die waiting for 
      lung transplantation (LTx) because it takes about 2 years to receive it in Japan. 
      We evaluated nutrition-related factors associated with waiting list mortality. 
      Seventy-six ILD patients were hospitalized in Kyoto University Hospital at 
      registration for LTx from 2013 to 2015. Among them, 40 patients were included and 
      analyzed. Patient background was as follows: female, 30%; age, 50.3 +/- 6.9 years; 
      body mass index, 21.1 +/- 4.0 kg/m(2) ; 6-minute walk distance (6MWD), 356 +/- 172 m; 
      serum albumin, 3.8 +/- 0.4 g/dL; serum transthyretin (TTR), 25.3 +/- 7.5 mg/dL; and 
      C-reactive protein, 0.5 +/- 0.5 mg/dL. Median observational period was 497 (range 
      97-1015) days, and median survival time was 550 (95% CI 414-686) days. Survival 
      rate was 47.5%, and mortality rate was 38.7/100 person-years. Cox analyses showed 
      that TTR (HR 0.791, 95% CI 0.633-0.988) and 6MWD (HR 0.795, 95% CI 0.674-0.938) 
      were independently correlated with mortality and were influenced by body fat mass 
      and leg skeletal muscle mass, respectively. It is suggested that nutritional 
      markers and exercise capacity are important prognostic markers in waitlisted 
      patients, but further study is needed to determine whether nutritional 
      intervention or exercise can change outcomes.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Oshima, Ayako
AU  - Oshima A
AUID- ORCID: 0000-0002-5946-6150
AD  - Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 
      Kyoto, Japan.
FAU - Nishimura, Akiko
AU  - Nishimura A
AUID- ORCID: 0000-0003-3670-9954
AD  - Department of Human Health Sciences, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Chen-Yoshikawa, Toyofumi F
AU  - Chen-Yoshikawa TF
AD  - Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Harashima, Shin-Ichi
AU  - Harashima SI
AUID- ORCID: 0000-0003-4813-0085
AD  - Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 
      Kyoto, Japan.
AD  - Department of Human Health Sciences, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
AD  - Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Komatsu, Teruya
AU  - Komatsu T
AD  - Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Handa, Tomohiro
AU  - Handa T
AD  - Department of Respiratory Medicine, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Aoyama, Akihiro
AU  - Aoyama A
AD  - Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Takahashi, Koji
AU  - Takahashi K
AD  - Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Ikeda, Masaki
AU  - Ikeda M
AD  - Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Oshima, Yohei
AU  - Oshima Y
AD  - Rehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
FAU - Ikezoe, Kohei
AU  - Ikezoe K
AD  - Department of Respiratory Medicine, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Sato, Susumu
AU  - Sato S
AD  - Department of Respiratory Medicine, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Isomi, Maki
AU  - Isomi M
AD  - Nursing Department, Kyoto University Hospital, Kyoto, Japan.
FAU - Shide, Kenichiro
AU  - Shide K
AD  - Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 
      Kyoto, Japan.
FAU - Date, Hiroshi
AU  - Date H
AD  - Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Japan.
FAU - Inagaki, Nobuya
AU  - Inagaki N
AD  - Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 
      Kyoto, Japan.
AD  - Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190512
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Diseases, Interstitial/*mortality/physiopathology/surgery
MH  - Lung Transplantation/*mortality
MH  - Male
MH  - Middle Aged
MH  - *Nutritional Status
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Waiting Lists/*mortality
OTO - NOTNLM
OT  - 6-minute walk distance
OT  - body composition
OT  - interstitial lung disease
OT  - lung transplantation
OT  - transthyretin
EDAT- 2019/04/20 06:00
MHDA- 2020/08/05 06:00
CRDT- 2019/04/20 06:00
PHST- 2018/09/19 00:00 [received]
PHST- 2019/02/22 00:00 [revised]
PHST- 2019/04/01 00:00 [accepted]
PHST- 2019/04/20 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/04/20 06:00 [entrez]
AID - 10.1111/ctr.13566 [doi]
PST - ppublish
SO  - Clin Transplant. 2019 Jun;33(6):e13566. doi: 10.1111/ctr.13566. Epub 2019 May 12.